Next Article in Journal
Body Fluid-Independent Effects of Dietary Salt Consumption in Chronic Kidney Disease
Previous Article in Journal
Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress
Open AccessArticle

Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial

1
Gerontology and Geriatrics Institute, Department of Medicine, University of Perugia, Santa Maria della Misericordia Hospital, 1 06123 P.le Menghini, Italy
2
Department of Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Santa Maria della Misericordia Hospital, 1 06123 P.le Menghini, Italy
3
Geriatric Medicine and Geriatric Emergency Care, Italian National Research Center on Aging (IRCCS INRCA), 60127 Ancona, Italy
4
Division of Orthopedics and Trauma Surgery, Santa Maria della Misericordia Hospital, 06123 Perugia, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2778; https://doi.org/10.3390/nu11112778
Received: 6 October 2019 / Revised: 12 November 2019 / Accepted: 12 November 2019 / Published: 15 November 2019
Vitamin D inadequacy is pervasive in the oldest-old. Many vitamin D metabolites are available for supplementation, their effects on the recovery of adequate serum levels remain unknown. We investigate the effects of supplementation with cholecalciferol (D3) and calcifediol (25D3) on serum levels of 25(OH)D, 1-25(OH)D, bone and inflammatory markers, ultimately identifying clinical predictors of successful treatment. Sixty-seven oldest-old individuals were randomized to weekly administration of 150 mcg of 25D3 or D3, from hospital admission to 7 months after discharge. Supplementation of 25D3 and D3 were associated with increasing serum levels of 25(OH)D (p < 0.001) and 1-25(OH)D (p = 0.01). Participants on 25D3 experienced a steeper rise than those on D3 (group*time interaction p = 0.01), after adjustment for intact parathyroid hormone (iPTH) levels the differences disappeared (intervention*iPTH interaction p = 0.04). Vitamin D supplementation was associated with a decreasing trend of iPTH and C-reactive protein (CRP) (p < 0.001). Polypharmacy and low handgrip strength were predictors of failure of intervention, independent of vitamin D metabolites. In conclusion, D3 and 25D3 supplementation significantly increase vitamin D serum levels in the oldest-old individuals, with a tendency of 25D3 to show a faster recovery of acceptable iPTH levels than D3. Polypharmacy and low muscle strength weaken the recovery of adequate vitamin D serum levels. View Full-Text
Keywords: calcifediol; cholecalciferol; bone markers; oldest-old; polypharmacy; sarcopenia calcifediol; cholecalciferol; bone markers; oldest-old; polypharmacy; sarcopenia
Show Figures

Figure 1

MDPI and ACS Style

Ruggiero, C.; Baroni, M.; Bini, V.; Brozzetti, A.; Parretti, L.; Zengarini, E.; Lapenna, M.; Antinolfi, P.; Falorni, A.; Mecocci, P.; Boccardi, V. Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial. Nutrients 2019, 11, 2778. https://doi.org/10.3390/nu11112778

AMA Style

Ruggiero C, Baroni M, Bini V, Brozzetti A, Parretti L, Zengarini E, Lapenna M, Antinolfi P, Falorni A, Mecocci P, Boccardi V. Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial. Nutrients. 2019; 11(11):2778. https://doi.org/10.3390/nu11112778

Chicago/Turabian Style

Ruggiero, Carmelinda; Baroni, Marta; Bini, Vittorio; Brozzetti, Annalisa; Parretti, Luca; Zengarini, Elisa; Lapenna, Maria; Antinolfi, Pierluigi; Falorni, Alberto; Mecocci, Patrizia; Boccardi, Virginia. 2019. "Effects of Weekly Supplementation of Cholecalciferol and Calcifediol Among the Oldest-Old People: Findings From a Randomized Pragmatic Clinical Trial" Nutrients 11, no. 11: 2778. https://doi.org/10.3390/nu11112778

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop