Next Article in Journal
Utility of Novel Hypochromia and Microcythemia Markers in Classifying Hematological and Iron Status in Male Athletes
Next Article in Special Issue
Multiple Sclerosis Patients Show Lower Bioavailable 25(OH)D and 1,25(OH)2D, but No Difference in Ratio of 25(OH)D/24,25(OH)2D and FGF23 Concentrations
Previous Article in Journal
Factors Associated with the Early Initiation of Breastfeeding in Economic Community of West African States (ECOWAS)
Previous Article in Special Issue
Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity
 
 
Review

Vitamin D Food Fortification and Nutritional Status in Children: A Systematic Review of Randomized Controlled Trials

1
Health Sciences Post-Graduation Program, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, S/N, Cidade Nova, Aracaju, 49060-108 Sergipe, Brazil
2
Nutrition Sciences Post-Graduation Program, Department of Nutrition, Federal University of Sergipe, Avenida Marechal Rondon, S/N, Jardim Rosa Elze, São Cristovão, 49100-000 Sergipe, Brazil
3
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. Armilla, 18100 Granada, Spain
4
Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain
5
CIBEROBN (Physiopathology of Obesity and Nutrition Network CB12/03/30038), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain
6
Investigative Pathology Laboratory, Federal University of Sergipe, Rua Cláudio Batista, S/N, Cidade Nova, Aracaju, 49060-108 Sergipe, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2766; https://doi.org/10.3390/nu11112766
Received: 27 September 2019 / Revised: 4 November 2019 / Accepted: 12 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Calcium, Vitamin D and Health)
Children are in the risk group for developing hypovitaminosis D. Several strategies are used to reduce this risk. Among these, fortification of foods with vitamin D (25(OH)D) has contributed to the achievement of nutritional needs. This systematic review aims to discuss food fortification as a strategy for maintenance or recovery of nutritional status related to vitamin D in children. The work was developed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and registered in the International prospective register of systematic reviews (PROSPERO) database (CRD42018052974). Randomized clinical trials with children up to 11 years old, who were offered vitamin D-fortified foods, and who presented 25(OH)D concentrations were used as eligibility criteria. After the selection stages, five studies were included, totaling 792 children of both sexes and aged between two and 11 years. Interventions offered 300–880 IU of vitamin D per day, for a period of 1.6–9 months, using fortified dairy products. In four of the five studies, there was an increase in the serum concentrations of 25(OH)D with the consumption of these foods; additionally, most children reached or maintained sufficiency status. Moreover, the consumption of vitamin D-fortified foods proved to be safe, with no concentrations of 25(OH)D > 250 nmol/L. Based on the above, the fortification of foods with vitamin D can help maintain or recover the nutritional status of this vitamin in children aged 2–11 years. However, it is necessary to perform additional randomized clinical trials in order to establish optimal doses of fortification, according to the peculiarities of each region. View Full-Text
Keywords: enriched food; child; cholecalciferol; ergocalciferols; dairy products enriched food; child; cholecalciferol; ergocalciferols; dairy products
Show Figures

Figure 1

MDPI and ACS Style

Brandão-Lima, P.N.; Santos, B.d.C.; Aguilera, C.M.; Freire, A.R.S.; Martins-Filho, P.R.S.; Pires, L.V. Vitamin D Food Fortification and Nutritional Status in Children: A Systematic Review of Randomized Controlled Trials. Nutrients 2019, 11, 2766. https://doi.org/10.3390/nu11112766

AMA Style

Brandão-Lima PN, Santos BdC, Aguilera CM, Freire ARS, Martins-Filho PRS, Pires LV. Vitamin D Food Fortification and Nutritional Status in Children: A Systematic Review of Randomized Controlled Trials. Nutrients. 2019; 11(11):2766. https://doi.org/10.3390/nu11112766

Chicago/Turabian Style

Brandão-Lima, Paula Nascimento, Beatriz da Cruz Santos, Concepción Maria Aguilera, Analícia Rocha Santos Freire, Paulo Ricardo Saquete Martins-Filho, and Liliane Viana Pires. 2019. "Vitamin D Food Fortification and Nutritional Status in Children: A Systematic Review of Randomized Controlled Trials" Nutrients 11, no. 11: 2766. https://doi.org/10.3390/nu11112766

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop