Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Care and Experiments
2.2. Blood Pressure Measurement
2.3. Determination of Nitric Oxide Analysis in the NTS
2.4. Renal Sympathetic Nerve Activity Recording
2.5. Baroreflex Sensitivity Recording
2.6. Assay of Serum Biochemical Parameters
2.7. Statistical Analysis
3. Results
3.1. Fructose Intake for One Week Significantly Increases Blood Pressure in Rats
3.2. Inhibition of Triglyceride does not Decrease Sympathetic-Nerve Activity after 1 Week of Fructose Intake
3.3. Fructose Intake Induces Sympathetic Hyperactivity and Decreases Nitric Oxide Level in Rats Fed Fructose for One Week
3.4. Fructose Intake for One Week Impairs Baroreflex Response Sensitivity in Rats
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
Abbreviations
BRS | baroreflex responses sensitivity |
CSF | cerebrospinal fluid |
DGAT1 | diacylglycerol acyltransferase 1 |
NTS | nucleus tractus solitarii |
NO | nitric oxide |
ROS | reactive oxygen species |
SNA | sympathetic nerve activity |
WKY | Wistar Kyoto |
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Chen, H.-H.; Chu, C.-H.; Wen, S.-W.; Lai, C.-C.; Cheng, P.-W.; Tseng, C.-J. Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients 2019, 11, 2581. https://doi.org/10.3390/nu11112581
Chen H-H, Chu C-H, Wen S-W, Lai C-C, Cheng P-W, Tseng C-J. Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients. 2019; 11(11):2581. https://doi.org/10.3390/nu11112581
Chicago/Turabian StyleChen, Hsin-Hung, Chih-Hsun Chu, Shu-Wei Wen, Chi-Cheng Lai, Pei-Wen Cheng, and Ching-Jiunn Tseng. 2019. "Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats" Nutrients 11, no. 11: 2581. https://doi.org/10.3390/nu11112581