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Open AccessArticle

Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats

by Hsin-Hung Chen 1,2,†, Chih-Hsun Chu 3,4,†, Shu-Wei Wen 1, Chi-Cheng Lai 5, Pei-Wen Cheng 1,6,* and Ching-Jiunn Tseng 1,6,7,8,*
1
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, [email protected] (H.-H.C.)
2
Yuh-Ing Junior College of Health Care & Management, Kaohsiung 821, Taiwan
3
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, [email protected]
4
Department of Nursing, Fooyin University, Kaohsiung 831, Taiwan
5
Cardiology, Kaohsiung Municipal United Hospital, Kaohsiung 804, Taiwan, [email protected]
6
Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan
7
Department of Pharmacology, National Defense Medical Center, Taipei 114, Taiwan
8
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2019, 11(11), 2581; https://doi.org/10.3390/nu11112581
Received: 16 September 2019 / Revised: 21 October 2019 / Accepted: 24 October 2019 / Published: 25 October 2019
(This article belongs to the Special Issue Fructose and Glucose Intake and Human Health)
Hypertension development with an increased intake of added sugar, especially excessive fructose intake, was shown in the National Health and Nutrition Examination Survey (NHANES) data. However, the mechanism underlying blood pressure (BP) elevation with increased fructose intake is still unclear. First, the present study showed that in rats fed 10% fructose for one week, BP and fructose/glucose levels increased in the central and peripheral nervous system. Furthermore, increased fructose intake resulted in an upregulation of fructose concentration in the cerebrospinal fluid. Second, consumption of excess fructose increased serum triglycerides. However, the inhibition of triglyceride production did not mitigate sympathetic nerve hyperactivity, but contributed to an insignificant decrease in BP. Finally, increased fructose intake reduced nitric oxide (NO) levels in the nucleus tractus solitarii (NTS) and reduced baroreflex sensitivity within a week. Collectively, the data suggested that fructose intake reduced NO levels in the NTS and caused baroreflex dysfunction, which further stimulated sympathetic nerve activity and induced the development of high BP. View Full-Text
Keywords: baroreflex sensitivity; blood pressure; fructose; nucleus tractus solitarii; sympathetic nerve activity; nitric oxide baroreflex sensitivity; blood pressure; fructose; nucleus tractus solitarii; sympathetic nerve activity; nitric oxide
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MDPI and ACS Style

Chen, H.-H.; Chu, C.-H.; Wen, S.-W.; Lai, C.-C.; Cheng, P.-W.; Tseng, C.-J. Excessive Fructose Intake Impairs Baroreflex Sensitivity and Led to Elevated Blood Pressure in Rats. Nutrients 2019, 11, 2581.

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