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Open AccessArticle

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

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Charité—Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Working Group Nutrition and Body Composition, Reinickendorfer Str. 61, 13347 Berlin, Germany
2
German Institute of Human Nutrition Potsdam - Rehbrücke, Department of Nutrition and Gerontology, Arthur—Scheunert—Allee 114-116, 14558 Nuthetal, Germany
3
Protestant Geriatric Center Berlin, Reinickendorfer Str. 61, 13347 Berlin, Germany
4
Charité—Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, Research Group on Geriatrics, Reinickendorfer Str. 61, 13347 Berlin, Germany
5
Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin and Berlin Institute of Health, BCRT—Berlin Institute of Health Centre for Regenerative Therapies, Föhrer Str. 15, 13353 Berlin, Germany
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DZHK—German Centre for Cardiovascular Research, Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany
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University of Potsdam, Institute of Nutritional Science, Arthur—Scheunert—Allee 114-116, 14558 Nuthetal, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2415; https://doi.org/10.3390/nu11102415
Received: 23 August 2019 / Revised: 30 September 2019 / Accepted: 1 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Diet and Fatigue)
Although malnutrition is frequent in the old, little is known about its association with fatigue. We evaluated the relation of self-reported severe weight loss with fatigue and the predictors for fatigue in old patients at hospital discharge. Severe weight loss was defined according to involuntary weight loss ≥5% in the last three months. We determined fatigue with the validated Brief Fatigue Inventory questionnaire. The regression analyses were adjusted for age, sex, number of comorbidities, medications/day, and BMI. Of 424 patients aged between 61 and 98 y, 34.1% had severe weight loss. Fatigue was higher in patients with severe weight loss (3.7 ± 2.3 vs. 3.2 ± 2.3 points, p = 0.021). In a multinomial regression model, weight loss was independently associated with higher risk for moderate fatigue (OR:1.172, CI:1.026–1.338, p = 0.019) and with increased risk for severe fatigue (OR:1.209, CI:1.047–1.395, p = 0.010) together with the number of medications/day (OR:1.220, CI:1.023-1.455, p = 0.027). In a binary regression model, severe weight loss predicted moderate-to-severe fatigue in the study population (OR:1.651, CI:1.052-2.590, p = 0.029). In summary, patients with self-reported severe weight loss at hospital discharge exhibited higher fatigue levels and severe weight loss was an independent predictor of moderate and severe fatigue, placing these patients at risk for impaired outcome in the post-hospital period. View Full-Text
Keywords: malnutrition; involuntary weight loss; post-hospital syndrome; fatigue; old adults malnutrition; involuntary weight loss; post-hospital syndrome; fatigue; old adults
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Franz, K.; Otten, L.; Müller-Werdan, U.; Doehner, W.; Norman, K. Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital. Nutrients 2019, 11, 2415.

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