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The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking

1
Nutritional Epidemiology, Department of Nutrition and Food Sciences, Rheinische Friedrich-Wilhelms-University Bonn, 53115 Bonn, Germany
2
German Institute of Human Nutrition Potsdam-Rehbrücke, Division of Epidemiology, 14558 Nuthetal, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2331; https://doi.org/10.3390/nu11102331
Received: 13 August 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 1 October 2019
Alcohol consumption is an important lifestyle factor that is associated with several health conditions and a behavioral link with smoking is well established. Metabolic alterations after alcohol consumption have yet to be comprehensively investigated. We studied the association of alcohol consumption with metabolite patterns (MPs) among 2433 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study, and a potential modification by smoking. Alcohol consumption was self-reported through dietary questionnaires and serum metabolites were measured by a targeted approach. The metabolites were summarized as MPs using the treelet transform analysis (TT). We fitted linear models with alcohol consumption continuously and in five categories. We stratified the continuously modelled alcohol consumption by smoking status. All models were adjusted for potential confounders. Among men, alcohol consumption was positively associated with six MPs and negatively associated with one MP. In women, alcohol consumption was inversely associated with one MP. Heavy consumers differed from other consumers with respect to the “Long and short chain acylcarnitines” MP. Our findings suggest that long and short chain acylcarnitines might play an important role in the adverse effects of heavy alcohol consumption on chronic diseases. The relations seem to depend on gender and smoking status. View Full-Text
Keywords: alcohol; smoking; targeted metabolomics; metabolite patterns; lipid metabolites; amino acids; acylcarnitines alcohol; smoking; targeted metabolomics; metabolite patterns; lipid metabolites; amino acids; acylcarnitines
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MDPI and ACS Style

Langenau, J.; Boeing, H.; Bergmann, M.M.; Nöthlings, U.; Oluwagbemigun, K. The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking. Nutrients 2019, 11, 2331. https://doi.org/10.3390/nu11102331

AMA Style

Langenau J, Boeing H, Bergmann MM, Nöthlings U, Oluwagbemigun K. The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking. Nutrients. 2019; 11(10):2331. https://doi.org/10.3390/nu11102331

Chicago/Turabian Style

Langenau, Julia, Heiner Boeing, Manuela M. Bergmann, Ute Nöthlings, and Kolade Oluwagbemigun. 2019. "The Association between Alcohol Consumption and Serum Metabolites and the Modifying Effect of Smoking" Nutrients 11, no. 10: 2331. https://doi.org/10.3390/nu11102331

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