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Article

Dietary Fiber, Whole Grains, and Head and Neck Cancer Prognosis: Findings from a Prospective Cohort Study

1
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
2
Department of Epidemiology, University of Michigan, Ann Arbor, MI 48103, USA
3
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
4
Department of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48103, USA
5
Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48103, USA
6
Carle Cancer Center, Carle Foundation Hospital, Urbana, IL 61801, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2304; https://doi.org/10.3390/nu11102304
Received: 30 August 2019 / Revised: 17 September 2019 / Accepted: 25 September 2019 / Published: 27 September 2019
(This article belongs to the Special Issue Nutrition and Cancer: From Prevention to Survivorship)
No studies, to date, have examined the relationship between dietary fiber and recurrence or survival after head and neck cancer diagnosis. The aim of this study was to determine whether pretreatment intake of dietary fiber or whole grains predicted recurrence and survival outcomes in newly diagnosed head and neck cancer (HNC) patients. This was a prospective cohort study of 463 participants baring a new head and neck cancer diagnosis who were recruited into the study prior to the initiation of any cancer therapy. Baseline (pre-treatment) dietary and clinical data were measured upon entry into the study cohort. Clinical outcomes were ascertained at annual medical reviews. Cox proportional hazard models were fit to examine the relationships between dietary fiber and whole grain intakes with recurrence and survival. There were 112 recurrence events, 121 deaths, and 77 cancer-related deaths during the study period. Pretreatment dietary fiber intake was inversely associated with risk of all-cause mortality (hazard ratio (HR): 0.37, 95% confidence interval (CI): 0.14–0.95, ptrend = 0.04). No statistically significant associations between whole grains and prognostic outcomes were found. We conclude that higher dietary fiber intake, prior to the initiation of treatment, may prolong survival time, in those with a new HNC diagnosis. View Full-Text
Keywords: epidemiology; survivorship; obesity; cancer; fruit; vegetables; diet; nutritional epidemiology; cancer survivors epidemiology; survivorship; obesity; cancer; fruit; vegetables; diet; nutritional epidemiology; cancer survivors
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MDPI and ACS Style

Maino Vieytes, C.A.; Mondul, A.M.; Li, Z.; Zarins, K.R.; Wolf, G.T.; Rozek, L.S.; Arthur, A.E. Dietary Fiber, Whole Grains, and Head and Neck Cancer Prognosis: Findings from a Prospective Cohort Study. Nutrients 2019, 11, 2304. https://doi.org/10.3390/nu11102304

AMA Style

Maino Vieytes CA, Mondul AM, Li Z, Zarins KR, Wolf GT, Rozek LS, Arthur AE. Dietary Fiber, Whole Grains, and Head and Neck Cancer Prognosis: Findings from a Prospective Cohort Study. Nutrients. 2019; 11(10):2304. https://doi.org/10.3390/nu11102304

Chicago/Turabian Style

Maino Vieytes, Christian A., Alison M. Mondul, Zonggui Li, Katie R. Zarins, Gregory T. Wolf, Laura S. Rozek, and Anna E. Arthur. 2019. "Dietary Fiber, Whole Grains, and Head and Neck Cancer Prognosis: Findings from a Prospective Cohort Study" Nutrients 11, no. 10: 2304. https://doi.org/10.3390/nu11102304

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