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Nutrients 2019, 11(1), 76; https://doi.org/10.3390/nu11010076

Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients

1
Department of Sport Medicine, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
2
University of Canberra Research Institute for Sport and Exercise (UCRISE), Cnr Allawoona St & Ginninderra Drive Bruce, ACT 2617, Australia
3
Department of Physiotherapy, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
4
Department of Sports Nutrition, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
5
Discipline of Physiotherapy, University of Canberra, Building 1/11 Kirinari St, Bruce ACT 2617, Australia
*
Author to whom correspondence should be addressed.
Received: 3 December 2018 / Revised: 21 December 2018 / Accepted: 24 December 2018 / Published: 2 January 2019
(This article belongs to the Special Issue Collagen and Human Health)
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Abstract

The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE®) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients. View Full-Text
Keywords: achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation
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Praet, S.F.; Purdam, C.R.; Welvaert, M.; Vlahovich, N.; Lovell, G.; Burke, L.M.; Gaida, J.E.; Manzanero, S.; Hughes, D.; Waddington, G. Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients. Nutrients 2019, 11, 76.

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