Nutrients 2019, 11(1), 76; https://doi.org/10.3390/nu11010076
Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients
Stephan F.E. Praet 1,2,*
, Craig R. Purdam 3, Marijke Welvaert 1,2, Nicole Vlahovich 1, Gregg Lovell 1, Louise M. Burke 4, Jamie E. Gaida 2,5, Silvia Manzanero 1, David Hughes 1 and Gordon Waddington 1,2
, Craig R. Purdam 3, Marijke Welvaert 1,2, Nicole Vlahovich 1, Gregg Lovell 1, Louise M. Burke 4, Jamie E. Gaida 2,5, Silvia Manzanero 1, David Hughes 1 and Gordon Waddington 1,2
1
Department of Sport Medicine, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
2
University of Canberra Research Institute for Sport and Exercise (UCRISE), Cnr Allawoona St & Ginninderra Drive Bruce, ACT 2617, Australia
3
Department of Physiotherapy, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
4
Department of Sports Nutrition, Australian Institute of Sport, Leverrier St, Bruce ACT 2617, Australia
5
Discipline of Physiotherapy, University of Canberra, Building 1/11 Kirinari St, Bruce ACT 2617, Australia
*
Author to whom correspondence should be addressed.
Received: 3 December 2018 / Revised: 21 December 2018 / Accepted: 24 December 2018 / Published: 2 January 2019
(This article belongs to the Special Issue Collagen and Human Health)
Abstract
The current pilot study investigates whether oral supplementation of specific collagen peptides improves symptoms and tendon vascularisation in patients with chronic mid-portion Achilles tendinopathy in combination with structured exercise. Participants were given a placebo or specific collagen peptides (TENDOFORTE®) in combination with a bi-daily calf-strengthening program for 6 months. Group AB received specific collagen peptides for the first 3 months before crossing over to placebo. Group BA received placebo first before crossing over to specific collagen peptides. At baseline (T1), 3 (T2) and 6 (T3) months, Victorian Institute of Sports Assessment–Achilles (VISA-A) questionnaires and microvascularity measurements through contrast-enhanced ultrasound were obtained in 20 patients. Linear mixed modeling statistics showed that after 3 months, VISA-A increased significantly for group AB with 12.6 (9.7; 15.5), while in group BA VISA-A increased only by 5.3 (2.3; 8.3) points. After crossing over group AB and BA showed subsequently a significant increase in VISA-A of, respectively, 5.9 (2.8; 9.0) and 17.7 (14.6; 20.7). No adverse advents were reported. Microvascularity decreased in both groups to a similar extent and was moderately associated with VISA-A (Rc2:0.68). We conclude that oral supplementation of specific collagen peptides may accelerate the clinical benefits of a well-structured calf-strengthening and return-to-running program in Achilles tendinopathy patients. View Full-TextKeywords:
achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation
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Praet, S.F.; Purdam, C.R.; Welvaert, M.; Vlahovich, N.; Lovell, G.; Burke, L.M.; Gaida, J.E.; Manzanero, S.; Hughes, D.; Waddington, G. Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients. Nutrients 2019, 11, 76.
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