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Open AccessArticle

Effect of Collagen Hydrolysates from Silver Carp Skin (Hypophthalmichthys molitrix) on Osteoporosis in Chronologically Aged Mice: Increasing Bone Remodeling

by Ling Zhang 1, Siqi Zhang 1, Hongdong Song 1 and Bo Li 1,2,*
1
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
2
Beijing Higher Institution Engineering Research Center of Animal Product, Beijing 100083, China
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1434; https://doi.org/10.3390/nu10101434
Received: 15 August 2018 / Revised: 27 September 2018 / Accepted: 30 September 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Collagen and Human Health)
Osteoporosis is a common skeletal disorder in humans and gelatin hydrolysates from mammals have been reported to improve osteoporosis. In this study, 13-month-old mice were used to evaluate the effects of collagen hydrolysates (CHs) from silver carp skin on osteoporosis. No significant differences were observed in mice body weight, spleen or thymus indices after daily intake of antioxidant collagen hydrolysates (ACH; 200 mg/kg body weight (bw) (LACH), 400 mg/kg bw (MACH), 800 mg/kg bw (HACH)), collagenase hydrolyzed collagen hydrolysates (CCH) or proline (400 mg/kg body weight) for eight weeks, respectively. ACH tended to improve bone mineral density, increase bone hydroxyproline content, enhance alkaline phosphatase (ALP) level and reduce tartrate-resistant acid phosphatase 5b (TRAP-5b) activity in serum, with significant differences observed between the MACH and model groups (p < 0.05). ACH exerted a better effect on osteoporosis than CCH at the identical dose, whereas proline had no significant effect on repairing osteoporosis compared to the model group. Western blotting results demonstrated that CHs mainly increased bone remodeling by stimulating the transforming growth factor β1 (TGF-β1)/Smad signaling pathway and improving the interaction between collagen and α2β1 integrin. The results indicated that CHs from fish could be applied to alleviate osteoporosis or treat bone loss. View Full-Text
Keywords: osteoporosis; chronologically aged mice; collagen hydrolysates; bone remodeling osteoporosis; chronologically aged mice; collagen hydrolysates; bone remodeling
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Zhang, L.; Zhang, S.; Song, H.; Li, B. Effect of Collagen Hydrolysates from Silver Carp Skin (Hypophthalmichthys molitrix) on Osteoporosis in Chronologically Aged Mice: Increasing Bone Remodeling. Nutrients 2018, 10, 1434.

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