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Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid

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UMR 1280 Physiopathologie des Adaptations Nutritionnelles (PhAN), INRA, Université de Nantes, 44 093 Nantes, France
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Centre de Recherche en Nutrition Humaine Ouest (CRNHO), 44 093 Nantes, France
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UMR 1087 Institut du Thorax, Université de Nantes, 44 007 Nantes, France
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EA 3859, Hémodynamique, Interaction Fibrose et Invasivité Tumorales Hépatiques (HIFIH), 49 933 Angers, France
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 194; https://doi.org/10.3390/nu11010194
Received: 10 December 2018 / Revised: 6 January 2019 / Accepted: 14 January 2019 / Published: 18 January 2019
Non-alcoholic steatohepatitis (NASH) is characterized by an excess of lipids and oxidative stress in the liver. Spirulina was reported to possess hypolipemic and antioxidative effects and might counteract NASH development. C57Bl/6J mice were fed a western diet (WD) during 25 weeks with or without spirulina liquid extract (SLE) at 2 different doses (WDS1 and WDS2 groups) in drinking water. Liver histology, inflammation, and oxidative stress were assessed as well as glucose tolerance status, lipid metabolism, and gallbladder bile acid profile. WDS2 gained significantly less weight than WD. Liver weight-to-body weight ratio and plasma alanine aminotransferase were significantly lower in WDS2 mice. A reduced liver fibrosis and NFκBp65 protein expression were measured in the supplemented group as a lower accumulation of superoxide anion, nitric oxide, and thiobarbituric reactive substances. WDS2 mice showed also a preserved glucose tolerance, a strong decrease of plasma cholesterol, and a significant increase of gallbladder ursodeoxycholic acid and β-muricholic acid. Our findings demonstrate a protective effect of SLE against WD induced NASH that is related to less inflammation and oxidative stress, a preserved glucose tolerance, and less hepatotoxic bile acid profile. View Full-Text
Keywords: spirulina liquid extract; non-alcoholic steatohepatitis; inflammation; oxidative stress; fibrosis; bile acids spirulina liquid extract; non-alcoholic steatohepatitis; inflammation; oxidative stress; fibrosis; bile acids
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Coué, M.; Tesse, A.; Falewée, J.; Aguesse, A.; Croyal, M.; Fizanne, L.; Chaigneau, J.; Boursier, J.; Ouguerram, K. Spirulina Liquid Extract Protects against Fibrosis Related to Non-Alcoholic Steatohepatitis and Increases Ursodeoxycholic Acid. Nutrients 2019, 11, 194.

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