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Nutrients 2019, 11(1), 150; https://doi.org/10.3390/nu11010150

Zinc Nutritional Status in Patients with Cystic Fibrosis

1
Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain
2
Department of Analytical Chemistry, Science Faculty, University of Valladolid, Campus Miguel Delibes, Calle Paseo de Belén, 7, 47011 Valladolid, Spain
3
Department of Paediatrics of the Faculty of Medicine, Valladolid University; Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 3 January 2019 / Accepted: 7 January 2019 / Published: 11 January 2019
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Abstract

Background: Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. Objective: The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients. Methods: A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted. Hypozincemia was determined by SZC while using atomic absorption spectrophotometry and dietary zinc deficiency by prospective 72-h dietary surveys. Results: Mean SZC (87.2 ± 16.7 μg/dL) and dietary zinc intake (97 ± 26.9% Dietary Reference Intake) were normal. Three of 17 patients with CF (17.6%) had hypozincemia and four (23.5%) had a dietary zinc deficiency. No patient with dietary zinc deficiency had hypozincemia. A positive and significant association was observed between SZC and Z-score of BMI-for-age (p = 0.048) and weight-for-height (p = 0.012) and between dietary zinc intake and energy intake (EI, p = 0.036) and Z-score of weight-for-high (p = 0.029). Conclusion: SZC was associated with the nutritional status, expressed as BMI (Body Mass Index) and weight-for-height Z score, and dietary zinc intake with EI and weight-for-height Z-score. No patient with hypozincemia had dietary zinc deficiency. This situation should alert us to a marginal zinc deficiency and it may explain why there were no overlapping cases between the two groups. We suggest that probably 41% of the cases in this study would be at elevated risk of zinc deficiency and a zinc supplementation may be considered. View Full-Text
Keywords: serum zinc concentration; hypozincemia; dietary zinc intake; dietary zinc deficiency; cystic fibrosis; marginal zinc deficiency serum zinc concentration; hypozincemia; dietary zinc intake; dietary zinc deficiency; cystic fibrosis; marginal zinc deficiency
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Escobedo Monge, M.F.; Barrado, E.; Alonso Vicente, C.; Redondo del Río, M.P.; Manuel Marugán de Miguelsanz, J. Zinc Nutritional Status in Patients with Cystic Fibrosis. Nutrients 2019, 11, 150.

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