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Nutrients 2018, 10(9), 1220; https://doi.org/10.3390/nu10091220

Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling–Weaning Period

1
Department of Agricultural and Life Sciences, Kyoto Prefectural University, Hangi-cho, Shimogamo, Sakyo-ku, Kyoto 606-8522, Japan
2
Laboratory of Nutritional Science for Animals, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwake-cho, Sakyo-ku, Kyoto 606-8502, Japan
3
Technical Center, Toyohashi Feed Mills, Kawada, Shinshiro, Aichi 441-1346, Japan
4
Kyoto Institute of Nutrition & Pathology, Furuikedani, Tachikawa, Ujitawara-cho, Kyoto 610-0231, Japan
*
Author to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 21 August 2018 / Accepted: 30 August 2018 / Published: 3 September 2018
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Abstract

Luminal short-chain fatty acids (SCFA) are rapidly absorbed from the intestine and subsequently utilized by the host as substrate for metabolic energy production. In pigs, the energy contribution of SCFA is thought to be 30–76%. However, since absorption and blood flow dynamics of SCFA in pigs, particularly during the suckling–weaning period, remain unclear, we aimed to elucidate these phenomena. Thirty-two piglets were used in the present work. Cecal vein blood and digesta, and portal and abdominal vein blood were sampled from suckling (7-, 14-, 21- and 28-day-old) and weaned (weaning at 21 and 28 days of age) piglets. Four piglets from each group were euthanized. SCFA concentrations in blood samples were analyzed by a highly sensitive gas chromatography-mass spectrometry technique. Age at weaning tended to affect SCFA absorption. For example, acetate and propionate concentrations in the cecal vein tended to be higher in piglets weaned at day 21 than at day 28. SCFA concentrations in the abdominal vein tended to differ from those in other veins. Mucosal gene expression analysis suggested that monocarboxylate transporter 1 and occludin were associated in absorption of SCFA from the lumen into the blood of piglets. View Full-Text
Keywords: short-chain fatty acid; hindgut fermentation; absorption from lumen; suckling; weaning short-chain fatty acid; hindgut fermentation; absorption from lumen; suckling; weaning
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Nakatani, M.; Inoue, R.; Tomonaga, S.; Fukuta, K.; Tsukahara, T. Production, Absorption, and Blood Flow Dynamics of Short-Chain Fatty Acids Produced by Fermentation in Piglet Hindgut during the Suckling–Weaning Period. Nutrients 2018, 10, 1220.

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