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Nutrients 2018, 10(9), 1221; https://doi.org/10.3390/nu10091221

Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds

1
Laboratory of Pharmacognosy and Natural Product-based Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea
2
Herbal Medicine Research Division, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
3
Korean Medicine Life Science, University of Science and Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 26 July 2018 / Revised: 29 August 2018 / Accepted: 31 August 2018 / Published: 3 September 2018
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Abstract

Obesity, a condition where excess body fat accumulates to the extent, causes a negative effect on health. Previously, we reported the extract of Dolichos lablab L. (DLL-Ex) inhibited high-fat diet (HFD)-induced increases in body weight and body fat mass and ameliorated increases in body weight. In the present work, we studyed the molecular mechanism for the inhibitory effect of DLL-Ex or Chikusetsusaponin IVa (CS-IVa), as isolated from Dolichos lablab L. (DLL) seeds extract, on adipocyte differentiation. We evaluated the effect of DLL-Ex, an anti-obesity agent, and CS-IVa, an active component of DLL-Ex, on 3T3-L1 cell differentiation via Oil red O assay and Q-PCR, along with their effects on CCAAT element binding protein alpha (C/EBPα), peroxisome proliferator-activated receptor gamma (PPARγ), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4) mRNA transcriptions. FAS and FABP4 protein expression levels after exposure to CS-IVa were also tested. The results showed that DLL-Ex and CS-IVa have potent inhibitory activity on adipocyte differentiation. Therefore, DLL and CS-IVa may be developed as a functional food material to treat obesity. View Full-Text
Keywords: Dolichos lablab L.; chikusetsusaponin IVa; triterpenoid saponin; anti-obesity; 3T3-L1 cell differentiation Dolichos lablab L.; chikusetsusaponin IVa; triterpenoid saponin; anti-obesity; 3T3-L1 cell differentiation
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Yin, J.; Seo, C.-S.; Hwang, I.H.; Lee, M.W.; Song, K.H. Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds. Nutrients 2018, 10, 1221.

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