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Nutrients 2018, 10(8), 1120; https://doi.org/10.3390/nu10081120

Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure

1
Department of Agriculture, Nutrition, & Veterinary Sciences, University of Nevada, Reno, NV 89557, USA
2
Center for Cardiovascular Research, University of Nevada, Reno, NV 89557, USA
3
Environmental Science & Health, University of Nevada, Reno, NV 89557, USA
*
Author to whom correspondence should be addressed.
Received: 1 August 2018 / Revised: 15 August 2018 / Accepted: 15 August 2018 / Published: 18 August 2018
(This article belongs to the Special Issue Gene-Diet Interactions)
Full-Text   |   PDF [1452 KB, uploaded 18 August 2018]   |  

Abstract

Approximately 5.7 million U.S. adults have been diagnosed with heart failure (HF). More concerning is that one in nine U.S. deaths included HF as a contributing cause. Current HF drugs (e.g., β-blockers, ACEi) target intracellular signaling cascades downstream of cell surface receptors to prevent cardiac pump dysfunction. However, these drugs fail to target other redundant intracellular signaling pathways and, therefore, limit drug efficacy. As such, it has been postulated that compounds designed to target shared downstream mediators of these signaling pathways would be more efficacious for the treatment of HF. Histone deacetylation has been linked as a key pathogenetic element for the development of HF. Lysine residues undergo diverse and reversible post-translational modifications that include acetylation and have historically been studied as epigenetic modifiers of histone tails within chromatin that provide an important mechanism for regulating gene expression. Of recent, bioactive compounds within our diet have been linked to the regulation of gene expression, in part, through regulation of the epi-genome. It has been reported that food bioactives regulate histone acetylation via direct regulation of writer (histone acetyl transferases, HATs) and eraser (histone deacetylases, HDACs) proteins. Therefore, bioactive food compounds offer unique therapeutic strategies as epigenetic modifiers of heart failure. This review will highlight food bio-actives as modifiers of histone deacetylase activity in the heart. View Full-Text
Keywords: heart failure; histone deacetylase; HDAC; HDAC inhibitors; food bio-actives; phytochemicals heart failure; histone deacetylase; HDAC; HDAC inhibitors; food bio-actives; phytochemicals
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Evans, L.W.; Ferguson, B.S. Food Bioactive HDAC Inhibitors in the Epigenetic Regulation of Heart Failure. Nutrients 2018, 10, 1120.

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