Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study

Chen, Pei-Yan; Fang, Ai-Ping; Wang, Xiao-Yan; Lan, Qiu-Ye; Liao, Gong-Cheng; Liu, Zhao-Yan; Zhang, Dao-Ming; Zhang, Yao-Yun; Chen, Yu-Ming; Zhu, Hui-Lian

doi:10.3390/nu10081113

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Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study

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Hui-Lian Zhu

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Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

Department of Hepatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Guangdong Provincial Key Laboratory of Food, Nutrition and Health; Guangzhou 510080, China

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Department of Medical Statistics & Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China

Author to whom correspondence should be addressed.

Nutrients 2018, 10(8), 1113; https://doi.org/10.3390/nu10081113

Received: 24 July 2018 / Revised: 9 August 2018 / Accepted: 15 August 2018 / Published: 17 August 2018

(This article belongs to the Special Issue Diet Quality and Health Outcomes)

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Abstract

Adherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by age and sex between September 2013 and October 2017 in South China. Dietary quality was assessed by the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI-2015), which manifests as scores of adhering to the 2016 Dietary Guidelines for Chinese and adhering to the 2015–2020 Dietary Guidelines for Americans, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models, adjusting for potential confounders. Higher scores in both the CHEI and HEI-2015 were associated with a lower risk of PLC (per 5-points increment of the total scores: OR: 0.43, 95% CI: 0.38–0.50 for CHEI; OR: 0.47, 95% CI: 0.40–0.55 for HEI-2015). The protective associations persisted significantly in the stratified analyses by sex, smoker status, alcohol consumption, HBV infection, and histological types of PLC, without statistical evidence for heterogeneity (p-interaction > 0.05). Closer adherence to the most recent dietary guidelines for Chinese or Americans may protect against PLC. View Full-Text

Keywords: dietary index; diet; liver cancer; risk factors; case-control study

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Chen, P.-Y.; Fang, A.-P.; Wang, X.-Y.; Lan, Q.-Y.; Liao, G.-C.; Liu, Z.-Y.; Zhang, D.-M.; Zhang, Y.-Y.; Chen, Y.-M.; Zhu, H.-L. Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study. Nutrients 2018, 10, 1113. https://doi.org/10.3390/nu10081113

AMA Style

Chen P-Y, Fang A-P, Wang X-Y, Lan Q-Y, Liao G-C, Liu Z-Y, Zhang D-M, Zhang Y-Y, Chen Y-M, Zhu H-L. Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study. Nutrients. 2018; 10(8):1113. https://doi.org/10.3390/nu10081113

Chicago/Turabian Style

Chen, Pei-Yan, Ai-Ping Fang, Xiao-Yan Wang, Qiu-Ye Lan, Gong-Cheng Liao, Zhao-Yan Liu, Dao-Ming Zhang, Yao-Yun Zhang, Yu-Ming Chen, and Hui-Lian Zhu. 2018. "Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study" Nutrients 10, no. 8: 1113. https://doi.org/10.3390/nu10081113

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Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study

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