Next Article in Journal
Determinants of Behaviour Change in a Multi-Component Telemonitoring Intervention for Community-Dwelling Older Adults
Next Article in Special Issue
Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study
Previous Article in Journal
Delphinidin Ameliorates Hepatic Triglyceride Accumulation in Human HepG2 Cells, but Not in Diet-Induced Obese Mice
Previous Article in Special Issue
Personalized Nutrition—Genes, Diet, and Related Interactive Parameters as Predictors of Cancer in Multiethnic Colorectal Cancer Families
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessFeature PaperArticle
Nutrients 2018, 10(8), 1061; https://doi.org/10.3390/nu10081061

Mediterranean Diet and Bladder Cancer Risk in Italy

1
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20133 Milan, Italy
2
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
3
Unit of Cancer Epidemiology, IRCCS CRO Aviano National Cancer Institute, 33081 Aviano, Italy
4
Department of Public Health and Pediatric Sciences, Università degli Studi di Torino, CTO Hospital, 10126 Turin, Italy
5
Unit of Epidemiology, Istituto Tumori Fondazione Pascale IRCCS, 80131 Naples, Italy
6
Laboratory of Translational Oncology & Functional Genomics, Department of Biomedical and Biotechnological Sciences, Università di Catania, 95124 Catania, Italy
7
Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 4 August 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Diet Quality and Health Outcomes)
Full-Text   |   PDF [247 KB, uploaded 10 August 2018]

Abstract

Previous studies have reported that Mediterranean diet is inversely related to the risk of several neoplasms; however, limited epidemiological data are available for bladder cancer. Thus, we examined the association between Mediterranean diet and this neoplasm in an Italian multicentric case-control study consisting of 690 bladder cancer cases and 665 controls. We assessed the adherence to the Mediterranean diet via a Mediterranean Diet Score (MDS), which represents the major characteristics of the Mediterranean diet and ranges from 0 to 9 (from minimal to maximal adherence, respectively). We derived odds ratios (ORs) of bladder cancer according to the MDS score from multiple logistic regression models, allowing for major confounding factors. The ORs of bladder cancer were 0.72 (95% confidence interval, CI, 0.54–0.98) for MDS of 4–5 and 0.66 (95% CI, 0.47–0.93) for MDS of 6–9 (p for trend = 0.02) compared to MDS = 0–3. Results were similar in strata of sex, age, and education, while the risk appeared somewhat lower in never-smokers and patients with pT1–pT4 bladder carcinomas. Among individual components of the MDS, we observed inverse associations for greater consumption of legumes, vegetables, and fish. In our study, which was carried out on an Italian population, the higher adherence to the Mediterranean diet was related to a lower risk of bladder cancer. View Full-Text
Keywords: Mediterranean diet; bladder cancer; case-control; prevention Mediterranean diet; bladder cancer; case-control; prevention
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Bravi, F.; Spei, M.-E.; Polesel, J.; Di Maso, M.; Montella, M.; Ferraroni, M.; Serraino, D.; Libra, M.; Negri, E.; La Vecchia, C.; Turati, F. Mediterranean Diet and Bladder Cancer Risk in Italy. Nutrients 2018, 10, 1061.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top