Cutaneous and Mucosal Manifestations Associated with Celiac Disease
by
Luis Rodrigo 1,*
, Valia Beteta-Gorriti 2, Nuria Alvarez 1, Celia Gómez de Castro 2, Alvaro De Dios 2, Laura Palacios 2 and Jorge Santos-Juanes 2,3,*
Luis Rodrigo 1,*, Valia Beteta-Gorriti 2, Nuria Alvarez 1, Celia Gómez de Castro 2, Alvaro De Dios 2, Laura Palacios 2 and Jorge Santos-Juanes 2,3,*
1
Gastroenterology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain
2
Dermatology Unit, Hospital Universitario Central de Asturias (HUCA), Avda. de Roma s/n, 33011 Oviedo, Asturias, Spain
3
Facultad de Medicina, Universidad de Oviedo, 33003 Oviedo, Asturias, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2018, 10(7), 800; https://doi.org/10.3390/nu10070800
Received: 9 May 2018 / Revised: 15 June 2018 / Accepted: 18 June 2018 / Published: 21 June 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
Celiac disease (CD) is an immune-mediated, gluten-induced enteropathy that affects predisposed individuals of all ages. Many patients with CD do not report gastrointestinal symptoms making it difficult to reach an early diagnosis. On the other hand, CD is related to a wide spectrum of extra-intestinal manifestations, with dermatitis herpetiformis (DH) being the best characterized. These associated conditions may be the clue to reaching the diagnosis of CD. Over the last few years, there have been multiple reports of the association between CD and several cutaneous manifestations that may improve with a gluten-free diet (GFD). The presence of some of these skin diseases, even in the absence of gastrointestinal symptoms, should give rise to an appropriate screening method for CD. The aim of this paper is to describe the different cutaneous manifestations that have been associated with CD and the possible mechanisms involved.
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Keywords:
celiac disease; dermatitis herpetiformis; urticaria; atopic dermatitis; psoriasis; recurrent aphtous ulceration; rosacea; alopecia areata; cutaneous vasculitis; gluten-free diet
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MDPI and ACS Style
Rodrigo, L.; Beteta-Gorriti, V.; Alvarez, N.; Gómez de Castro, C.; De Dios, A.; Palacios, L.; Santos-Juanes, J. Cutaneous and Mucosal Manifestations Associated with Celiac Disease. Nutrients 2018, 10, 800.
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