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Open AccessArticle

Whey Protein Concentrate WPC-80 Improves Antioxidant Defense Systems in the Salivary Glands of 14-Month Wistar Rats

1
Department of Experimental Pharmacology, Medical University of Bialystok, 37 Szpitalna Street, 15-767 Bialystok, Poland
2
ZOZ Clinic of Dentistry and Medicine, E. and B. Falkowscy CLP., 17B Zarzecze Street, 16-300 Augustów, Poland
3
Department of Physiology, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland
4
Servier Polska LTD, 10 Jana Kazimierza Street, 01-248 Warszawa, Poland
5
Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 17 Waszyngtona Street, 15-274 Białystok, Poland
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Department of Statistics and Medical Informatics, Medical University of Bialystok, 37 Szpitalna Street, 15-767 Bialystok, Poland
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Department of Conservative Dentistry, Medical University of Bialystok, 24a M. Sklodowskiej-Curie Street, 15-274 Bialystok, Poland
*
Author to whom correspondence should be addressed.
The authors had equal participation, their surnames in alphabetical order.
Nutrients 2018, 10(6), 782; https://doi.org/10.3390/nu10060782
Received: 14 May 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 17 June 2018
(This article belongs to the Special Issue Antioxidant Intake in Older Adults and Elderly People)
Whey protein concentrate (WPC) is characterized by powerful antioxidant properties, but its effect on redox homeostasis of salivary glands of aging organisms is still unknown. In this study, we are the first to evaluate the antioxidant barrier of salivary glands of 14-month Wistar rats fed WPC-80. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) as well as concentrations of reduced glutathione (GSH) are estimated in the submandibular and parotid glands of rats administered WPC-80 intragastrically for a period of 7 and 14 days. We demonstrate a significant increase in GSH, GPx and SOD in the salivary glands of rats fed WPC-80 for 14 days and a significant increase in TAS, GPx and SOD in the parotid glands of rats fed WPC-80 for 7 days compared to control rats. The beneficial effects of WPC-80 on salivary glands are also demonstrated by lower TOS and OSI in the parotid glands of rats fed WPC-80 compared to the submandibular glands. In summary, we demonstrate that WPC-80 improves redox homeostasis in salivary glands, particularly in the parotid glands of old rats. View Full-Text
Keywords: oxidative stress; salivary glands; aging; whey; salivary antioxidants oxidative stress; salivary glands; aging; whey; salivary antioxidants
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MDPI and ACS Style

Falkowski, M.; Maciejczyk, M.; Koprowicz, T.; Mikołuć, B.; Milewska, A.; Zalewska, A.; Car, H. Whey Protein Concentrate WPC-80 Improves Antioxidant Defense Systems in the Salivary Glands of 14-Month Wistar Rats. Nutrients 2018, 10, 782.

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