Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study

Baghdasarian, Siyouneh; Lin, Hsuan-Ping; Pickering, Richard T.; Mott, Melanie M.; Singer, Martha R.; Bradlee, M. Loring; Moore, Lynn L.

doi:10.3390/nu10060665

Open AccessArticle

Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study

by

Siyouneh Baghdasarian

,

Hsuan-Ping Lin

,

Richard T. Pickering

,

Melanie M. Mott

,

Martha R. Singer

,

M. Loring Bradlee

and

Lynn L. Moore

^*

Department of Medicine Section of Preventative Medicine and Epidemiology, Boston University School of Medicine, Boston, MA 02118, USA

^*

Author to whom correspondence should be addressed.

Nutrients 2018, 10(6), 665; https://doi.org/10.3390/nu10060665

Submission received: 1 May 2018 / Revised: 15 May 2018 / Accepted: 18 May 2018 / Published: 24 May 2018

(This article belongs to the Special Issue Dietary Cholesterol:Is It Related to Chronic Disease)

Download

Browse Figure

Versions Notes

Abstract

Identification of diet and lifestyle risk factors for prevention of type 2 diabetes mellitus (T2DM) is of great importance. The specific role of dietary cholesterol (DC) in T2DM risk is unclear. This study uses data from 2192 Framingham Offspring Study subjects to estimate the effects of DC alone and in combination with markers of a healthy diet and other lifestyle factors on fasting glucose and risk of T2DM or impaired fasting glucose (IFG) over 20 years of follow-up. Dietary data were derived from two sets of three-day food records. Statistical methods included mixed linear regression and Cox proportional hazard’s modeling to adjust for confounding. There were no statistically significant differences in glucose levels over 20 years of follow-up across DC intake categories (<200, 200–<300, and ≥300 mg/day) and no increased risk of T2DM/IFG associated with higher intakes. The HR for T2DM/IFG associated with consumption of ≥300 mg/day of DC was 0.87 (95% CI: 0.68–1.10). In contrast, subjects with lower intakes of fish, whole grains, and fiber had higher T2DM/IFG risk. DC consumption was not associated with fasting glucose levels or risk of T2DM/IFG over 20 years of follow-up.

Keywords: dietary cholesterol; eggs; type 2 diabetes mellitus; fasting glucose; prospective study

Share and Cite

MDPI and ACS Style

Baghdasarian, S.; Lin, H.-P.; Pickering, R.T.; Mott, M.M.; Singer, M.R.; Bradlee, M.L.; Moore, L.L. Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study. Nutrients 2018, 10, 665. https://doi.org/10.3390/nu10060665

AMA Style

Baghdasarian S, Lin H-P, Pickering RT, Mott MM, Singer MR, Bradlee ML, Moore LL. Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study. Nutrients. 2018; 10(6):665. https://doi.org/10.3390/nu10060665

Chicago/Turabian Style

Baghdasarian, Siyouneh, Hsuan-Ping Lin, Richard T. Pickering, Melanie M. Mott, Martha R. Singer, M. Loring Bradlee, and Lynn L. Moore. 2018. "Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study" Nutrients 10, no. 6: 665. https://doi.org/10.3390/nu10060665

APA Style

Baghdasarian, S., Lin, H.-P., Pickering, R. T., Mott, M. M., Singer, M. R., Bradlee, M. L., & Moore, L. L. (2018). Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study. Nutrients, 10(6), 665. https://doi.org/10.3390/nu10060665

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI