Next Article in Journal
Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children
Next Article in Special Issue
Extra-Intestinal Manifestation of Celiac Disease in Children
Previous Article in Journal
The Effect of Low-Carbohydrate Diet on Glycemic Control in Patients with Type 2 Diabetes Mellitus
Previous Article in Special Issue
Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis
Open AccessArticle

Quality of Life in Patients with Gluten Neuropathy: A Case-Controlled Study

Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, South Yorkshire, UK
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 662; https://doi.org/10.3390/nu10060662
Received: 15 April 2018 / Revised: 10 May 2018 / Accepted: 15 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
Background: Gluten neuropathy (GN) is defined as an otherwise idiopathic peripheral neuropathy in the presence of serological evidence of gluten sensitivity (positive native gliadin antibodies and/or transglutaminase or endomysium antibodies). We aimed to compare the quality of life (QoL) of GN patients with that of control subjects and to investigate the effects of a gluten-free diet (GFD) on the QoL. Methods: All consecutive patients with GN attending a specialist neuropathy clinic were invited to participate. The Overall Neuropathy Limitations Scale (ONLS) was used to assess the severity of the neuropathy. The 36-Item Short Form Survey (SF-36) questionnaire was used to measure participants’ QoL. A strict GFD was defined as effectively being able to eliminate all circulating gluten sensitivity-related antibodies. Results: Fifty-three patients with GN and 53 age- and gender-matched controls were recruited. Compared to controls, GN patients showed significantly worse scores in the physical functioning, role limitations due to physical health, energy/fatigue, and general health subdomains of the SF-36. After adjusting for age, gender, and disease severity, being on a strict GFD correlated with better SF-36 scores in the pain domain of the SF-36 (beta 0.317, p = 0.019) and in the overall health change domain of the SF-36 (beta 0.306, p = 0.017). Conclusion: In GN patients, physical dysfunctioning is the major determinant of poor QoL compared to controls. Routine checking of the elimination of gluten sensitivity-related antibodies that results from a strict GFD should be encouraged, as such elimination ameliorates the overall pain and health scores, indicating a better QoL. View Full-Text
Keywords: gluten neuropathy; coeliac disease; gluten free diet; quality of life; male gluten neuropathy; coeliac disease; gluten free diet; quality of life; male
MDPI and ACS Style

Zis, P.; Sarrigiannis, P.G.; Rao, D.G.; Hadjivassiliou, M. Quality of Life in Patients with Gluten Neuropathy: A Case-Controlled Study. Nutrients 2018, 10, 662.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop