Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children
1
Pediatric Gastroenterology Hepatology and Nutrition, Ospedale Papa Giovanni XXIII, 24127 Bergamo, Italy
2
Pediatric Gastroenterology Hepatology and Nutrition, Hôpital Necker Enfants Malades, 75015 Paris, France
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(6), 664; https://doi.org/10.3390/nu10060664
Received: 29 March 2018 / Revised: 21 May 2018 / Accepted: 22 May 2018 / Published: 24 May 2018
(This article belongs to the Special Issue Nutrition in Pediatric Gastroenterology: Selected Papers from SIGENP)
Intestinal failure-associated liver disease (IFALD) is a threatening complication for children on long-term parenteral nutrition because of intestinal failure. When progressive and intractable, it may jeopardize intestinal rehabilitation and lead to combined liver and intestinal transplantation. The institution of dedicated intestinal failure centers has dramatically decreased the incidence of such complication. IFALD may rapidly fade away if very early management aimed at preventing progression to end-stage liver disease is provided. In this review, we address the etiology and risk factors of IFALD in order to introduce pillars of prevention (nutritional management and catheter-related infections control). The latest evidence of therapeutic strategies, such as medical and surgical treatments, is also discussed.
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Keywords:
intestinal failure; liver disease; parenteral nutrition; children; prevention; treatment
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MDPI and ACS Style
Norsa, L.; Nicastro, E.; Di Giorgio, A.; Lacaille, F.; D’Antiga, L. Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children. Nutrients 2018, 10, 664. https://doi.org/10.3390/nu10060664
AMA Style
Norsa L, Nicastro E, Di Giorgio A, Lacaille F, D’Antiga L. Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children. Nutrients. 2018; 10(6):664. https://doi.org/10.3390/nu10060664
Chicago/Turabian StyleNorsa, Lorenzo; Nicastro, Emanuele; Di Giorgio, Angelo; Lacaille, Florence; D’Antiga, Lorenzo. 2018. "Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children" Nutrients 10, no. 6: 664. https://doi.org/10.3390/nu10060664
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