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Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States

1,2, 2 and 1,2,*
School of Public Health, Jiamusi University, Jiamusi 154007, China
School of Public Health, Harbin Medical University, Harbin 150081, China
Author to whom correspondence should be addressed.
Nutrients 2018, 10(5), 568;
Received: 5 April 2018 / Revised: 27 April 2018 / Accepted: 2 May 2018 / Published: 5 May 2018
(This article belongs to the Special Issue Health Effects of Dietary Zinc)
PDF [257 KB, uploaded 5 May 2018]


We aim to explore the associations between dietary zinc intake and hyperuricemia (HU) in United States (US) adults. 24,975 US adults aged 20 years or older from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2014 were stratified into quintiles based on zinc intake. All dietary intake measured through 24-h dietary recalls. Multivariable logistic regression analysis was performed to examine the association between zinc intake and HU after adjustment for possible confounders. For males, compared with respondents consuming less than 7.33 mg zinc daily, the adjusted odds ratios (ORs) were 0.83 (95% CI, 0.71, 0.97) among those consuming 10.26–13.54 mg zinc daily, 0.78 (95% CI, 0.63–0.96) among those consuming 18.50 mg or greater, and p for the trend was 0.0134. For females, compared with respondents consuming less than 5.38 mg zinc daily, the OR was 0.78 (95% CI, 0.63, 0.97) among those consuming 9.64–12.93 mg zinc daily, and p for the trend was 0.3024. Our findings indicated that dietary zinc intake is inversely associated with HU in US men and women, independent of some major confounding factors. View Full-Text
Keywords: hyperuricemia; zinc; NHANES; cross-sectional study hyperuricemia; zinc; NHANES; cross-sectional study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Zhang, Y.; Liu, Y.; Qiu, H. Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States. Nutrients 2018, 10, 568.

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