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Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes

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Service of Molecular Biology in Medicine, Civil Hospital Fray Antonio Alcalde, 44280 Guadalajara, Mexico
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Department of Molecular Biology and Genomic, Health Sciences University Center, University of Guadalajara, 44340 Guadalajara, Mexico
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Department of Microbiology and Parasitology, Health Sciences University Center, University of Guadalajara, 44340 Guadalajara, Mexico
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Department of Human Reproduction, Health Sciences University Center, University of Guadalajara, 44340 Guadalajara, Mexico
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Institute of Research in Biomedical Sciences, University of Guadalajara. 44340 Guadalajara, Mexico
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Author to whom correspondence should be addressed.
Nutrients 2018, 10(4), 447; https://doi.org/10.3390/nu10040447
Received: 28 February 2018 / Revised: 27 March 2018 / Accepted: 2 April 2018 / Published: 4 April 2018
Metabolically healthy (MH) and metabolically unhealthy (MUH) phenotypes can be present in any subject independently of their body mass index (BMI). However, factors related to the presence of these phenotypes are poorly understood. Therefore, the aim of this cross-sectional study is to describe the prevalence and characteristics associated with the MH and MUH phenotypes in Mexican subjects with different BMI categories. Anthropometric and biochemical parameters were evaluated after 12 h of fasting. HMW (High Molecular Weight) adiponectin and insulin levels were measured by ELISA (enzyme-linked immunosorbent assay). A total of 345 subjects were included, of which, 73.9% were women. The prevalence of the MH phenotype was 69.9%, 46.7%, and 19% in normal weight, overweight, and obesity, respectively. ROC (receiver operating characteristic) curve analysis showed that the waist circumference demonstrated a statistical significance (p < 0.01) in detecting the MUH phenotype in each BMI group only in women. Furthermore, subjects with lower HMW adiponectin levels showed a 2.1 increased risk of presenting the MUH phenotype. In conclusion, in this Mexican population, waist circumference was an anthropometric parameter that identified women with the MUH phenotype in all BMI categories and hypoadiponectinemia was a risk factor for the presence of this phenotype. View Full-Text
Keywords: metabolically healthy phenotype; prevalence; anthropometric parameters; adiponectin metabolically healthy phenotype; prevalence; anthropometric parameters; adiponectin
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Torres-Castillo, N.; Campos-Perez, W.; Gonzalez-Becerra, K.; Hernandez-Cañaveral, I.; Vizmanos, B.; Muñoz-Valle, J.; Martinez-Lopez, E. Waist Circumference Is an Anthropometric Parameter That Identifies Women with Metabolically Unhealthy Phenotypes. Nutrients 2018, 10, 447.

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