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Nutrients
Volume 10
Issue 4
10.3390/nu10040398
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Article

Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients

by
Evertine Wesselink
1,
Renate M. Winkels
1,
Harm Van Baar
1,
Anne J. M. R. Geijsen
1,
Moniek Van Zutphen
1,
Henk K. Van Halteren
2,
Bibi M. E. Hansson
3,
Sandra A. Radema
4,
Johannes H. W. De Wilt
5,
Ellen Kampman
1 and
Dieuwertje E. G. Kok
1,*
1
Division of Human Nutrition, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands
2
Department of Internal Medicine, Admiraal de Ruyter Ziekenhuis, ‘s-Gravenpolderseweg 114, 4462 RA Goes, The Netherlands
3
Department of Surgery, Canisius Wilhelmina Ziekenhuis, Weg door het Jonkerbos 100, 6532 SZ Nijmegen, The Netherlands
4
Department of Medical Oncology, Radboud University Medical Centre, Geert Grooteplein-Zuid 22, 6525 GA Nijmegen, The Netherlands
5
Department of Surgery, Radboud University Medical Centre, Geert Grooteplein-Zuid 22, 6525 GA Nijmegen, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(4), 398; https://doi.org/10.3390/nu10040398
Submission received: 15 February 2018 / Revised: 15 March 2018 / Accepted: 21 March 2018 / Published: 23 March 2018
(This article belongs to the Special Issue Magnesium Intake and Human Health)
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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β −1.08, 95% CI −1.95, −0.22) and after chemotherapy (β −0.93, 95% CI −1.81, −0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
Keywords: calcium; chemotherapy; colorectal cancer; magnesium; neuropathy; oxaliplatin calcium; chemotherapy; colorectal cancer; magnesium; neuropathy; oxaliplatin

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MDPI and ACS Style

Wesselink, E.; Winkels, R.M.; Van Baar, H.; Geijsen, A.J.M.R.; Van Zutphen, M.; Van Halteren, H.K.; Hansson, B.M.E.; Radema, S.A.; De Wilt, J.H.W.; Kampman, E.; et al. Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Nutrients 2018, 10, 398. https://doi.org/10.3390/nu10040398

AMA Style

Wesselink E, Winkels RM, Van Baar H, Geijsen AJMR, Van Zutphen M, Van Halteren HK, Hansson BME, Radema SA, De Wilt JHW, Kampman E, et al. Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Nutrients. 2018; 10(4):398. https://doi.org/10.3390/nu10040398

Chicago/Turabian Style

Wesselink, Evertine, Renate M. Winkels, Harm Van Baar, Anne J. M. R. Geijsen, Moniek Van Zutphen, Henk K. Van Halteren, Bibi M. E. Hansson, Sandra A. Radema, Johannes H. W. De Wilt, Ellen Kampman, and et al. 2018. "Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients" Nutrients 10, no. 4: 398. https://doi.org/10.3390/nu10040398

APA Style

Wesselink, E., Winkels, R. M., Van Baar, H., Geijsen, A. J. M. R., Van Zutphen, M., Van Halteren, H. K., Hansson, B. M. E., Radema, S. A., De Wilt, J. H. W., Kampman, E., & Kok, D. E. G. (2018). Dietary Intake of Magnesium or Calcium and Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer Patients. Nutrients, 10(4), 398. https://doi.org/10.3390/nu10040398

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