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Open AccessArticle

Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue

1
College of Pharmacy, Yonsei University, Incheon 21983, Korea
2
College of Pharmacy, Pusan National University, Busan 46241, Korea
3
College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National University, Seoul 08826, Korea
4
College of Medicine, Dankook University, Cheonan-si, Chungcheongnam-do 31116, Korea
5
Laboratory of Developmental Biology and Genomics, BK21 Program Plus for Advanced Veterinary Science, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
6
Korea Mouse Phenotyping Center (KMPC), Seoul 08826, Korea
7
Vital Beautie Division, Amorepacific R&D Center, 314-1 Bora-dong, Giheung-gu, Yongin-si, Gyeonggi-do 17074, Korea
*
Author to whom correspondence should be addressed.
The authors are equally contributed to this work.
Nutrients 2018, 10(12), 1962; https://doi.org/10.3390/nu10121962
Received: 11 November 2018 / Revised: 29 November 2018 / Accepted: 10 December 2018 / Published: 12 December 2018
(This article belongs to the Special Issue Diet and Energy Metabolism)
Myricetin is a biologically active natural polyphenol with beneficial effects on metabolic health. This study aimed to examine the effects of myricetin on the expression levels of genes involved in lipolysis and mitochondrial respiration in adipocytes and the anti-obesity potential of myricetin. The results indicated that myricetin reduced triglyceride (TG) content and increased mitochondrial content and oxygen consumption rate (OCR) in adipocytes in vitro. To determine anti-obesity effect of myricetin, C57BL6/J mice were fed a high-fat diet (HFD) for eight weeks and then treated with myricetin (10 mg/kg) for 2 weeks. The in vivo treatment of myricetin reduced body weight by 11%. Furthermore, it improved the glucose tolerance, and increased fatty acid consumption of HFD-fed mice. Myricetin treatment increased Sirt3 expression and reduced the acetylation of mitochondrial proteins in adipose tissue. Finally, the knockdown of Sirt3 in adipocytes reduced the myricetin-induced increase in mitochondrial oxygen consumption rate by about 27% compared to controls. Our results indicated that myricetin exerted anti-obesity effects through the upregulation of Sirt3 expression and mitochondrial metabolism in adipose tissue. View Full-Text
Keywords: myricetin; adipose tissue; SIRT3; anti-obesity; mitochondria myricetin; adipose tissue; SIRT3; anti-obesity; mitochondria
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MDPI and ACS Style

Akindehin, S.; Jung, Y.-S.; Kim, S.-N.; Son, Y.-H.; Lee, I.; Seong, J.K.; Jeong, H.W.; Lee, Y.-H. Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue. Nutrients 2018, 10, 1962.

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