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Nutrients 2018, 10(12), 1925;

Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability

Prolabin & Tefarm, Spin-Off Un. of University of Perugia, Via Dell’Acciaio 9, Ponte Felcino, 06134 Perugia, Italy
Department of Chemistry, Biology and Biotechnologies, University of Perugia, Via Elce di Sotto 8, 06123 Perugia, Italy
Department of Experimental Medicine, Perugia Medical School, University of Perugia, Piazza Lucio Severi 1, 06132 Perugia, Italy
S&R Farmaceutici S.p.A Bastia Umbra, 08063 Perugia Italy
Department of Biology, Faculty of Natural Science and Health Care, Batumi Shota Rustaveli State University, 6010 Batumi, Georgia
Department of Veterinary Science, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
Department of Pharmaceutical Sciences, University of Perugia, Via A. Fabretti 48, 06123 Perugia, Italy
Author to whom correspondence should be addressed.
Received: 24 October 2018 / Revised: 21 November 2018 / Accepted: 26 November 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Benefits of Resveratrol Supplementation)
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Resveratrol, because of its low solubility in water and its high membrane permeability, is collocated in the second class of the biopharmaceutical classification system, with limited bioavailability due to its dissolution rate. Solid dispersion of resveratrol supported on Magnesium DiHydroxide ([email protected]) was evaluated to improve solubility and increase bioavailability of resveratrol. Fluorimetric microscopy analysis displays three types of microparticles with similar size: Type 1 that emitted preferably fluorescence at 445 nm with bandwidth of 50 nm, type 2 that emitted preferably fluorescence at 605 nm with bandwidth of 70 nm and type 3 that is non-fluorescent. Micronized pure resveratrol displays only microparticles type 1 whereas type 3 are associated to pure magnesium dihydroxide. Dissolution test in simulated gastric environment resveratrol derived from [email protected] in comparison to resveratrol alone displayed better solubility. A 3-fold increase of resveratrol bioavailability was observed after oral administration of 50 mg/kg of resveratrol from [email protected] in rabbits. We hypothesize that type 2 microparticles represent magnesium dihydroxide microparticles with a resveratrol shell and that they are responsible for the improved resveratrol solubility and bioavailability of [email protected] View Full-Text
Keywords: resveratrol; magnesium dihydroxide; solubility; bioavailability; dissolution rate; microparticles resveratrol; magnesium dihydroxide; solubility; bioavailability; dissolution rate; microparticles

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Spogli, R.; Bastianini, M.; Ragonese, F.; Iannitti, R.G.; Monarca, L.; Bastioli, F.; Nakashidze, I.; Brecchia, G.; Menchetti, L.; Codini, M.; Arcuri, C.; Mancinelli, L.; Fioretti, B. Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide ([email protected]) Microparticles Improves Oral Bioavailability. Nutrients 2018, 10, 1925.

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