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Open AccessArticle

Assessment of Muscle Wasting in Long-Stay ICU Patients Using a New Ultrasound Protocol

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Department of Radiology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad de Las Palmas de Gran Canaria, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain
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Department of Mathematics, Universidad de Las Palmas de Gran Canaria, 35010 Las Palmas de Gran Canaria, Spain
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Department of Neurology, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad of Las Palmas de Gran Canaria, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain
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Department of Intensive Care, Hospital Universitario de Gran Canaria Dr. Negrín, Universidad of Las Palmas de Gran Canaria, Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain
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Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 1849; https://doi.org/10.3390/nu10121849
Received: 8 October 2018 / Revised: 11 November 2018 / Accepted: 27 November 2018 / Published: 1 December 2018
There is currently no standardized procedure to assess sarcopenia in long-stay catabolic patients. Our aim is to analyze a novel ultrasound muscle assessment protocol in these patients versus healthy controls, by carrying out a prospective observational study. We designed a new ultrasound protocol that assesses quadriceps rectus femoris (QRF) muscle quality in real-time B-mode, color-Doppler, and M-mode ultrasound, and evaluates QRF intramuscular central tendon thickness, cross-sectional area, and muscle thickness in ultrasound B-mode. Logistic regression was performed as a multivariable analysis on 29 cases and 19 controls. The QRF muscle area and thickness were shown to significantly decrease (p ≤ 0.001), and the central tendon thickness significantly increased (p = 0.047) in cases versus controls. The QRF muscle echogenicity and angiogenic activity fasciculations, subcutaneous edema, and intramuscular fluid were also significantly different between the two groups (p < 0.001). The selected variables in the multivariate logit analysis were the muscle area (OR per cm2 = 0.07; 95% confidence interval (CI) = 0.012–0.41) and the central tendon thickness (OR per mm 1.887; 95% CI = 2.66–13.38). View Full-Text
Keywords: ultrasound; sarcopenia; quadriceps femoris; muscle weakness; muscle mass; critical illness; Bayesian prediction ultrasound; sarcopenia; quadriceps femoris; muscle weakness; muscle mass; critical illness; Bayesian prediction
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Hernández-Socorro, C.R.; Saavedra, P.; López-Fernández, J.C.; Ruiz-Santana, S. Assessment of Muscle Wasting in Long-Stay ICU Patients Using a New Ultrasound Protocol. Nutrients 2018, 10, 1849.

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