Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels
AbstractThe relationship between dietary n-6 fatty acids and hypertension is not clear. The metabolic products of n-6 fatty acids include those that control blood pressure, such as prostaglandin and thromboxane, and that differ depending on the extent of glucose tolerance. This cross-sectional study investigated the association of dietary n-6 fatty acid intake on hypertension, and the effects of glycated hemoglobin (HbA1c) value in 633 Japanese subjects aged 40 years and older. Dietary intake was measured using a validated brief self-administered diet history questionnaire. We defined hypertension as the use of antihypertensive medication or a blood pressure of 140/90 mmHg. The prevalence of hypertension was 55.3%. A high n-6 fatty acids intake inversely correlated with hypertension in subjects with HbA1c values less than 6.5% (odds ratio, 0.857; 95% confidence interval, 0.744 to 0.987). On the contrary, in subjects with an HbA1c value of 6.5% or higher, the n-6 fatty acids intake was significantly associated with hypertension (odds ratio, 3.618; 95% confidence interval, 1.019 to 12.84). Regular dietary n-6 fatty acid intake may contribute to the prevention and treatment of hypertension in a healthy general population. By contrast, in subjects with diabetes, regular n-6 fatty acids intake may increase the risk of hypertension. View Full-Text
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Nakamura, H.; Hara, A.; Tsujiguchi, H.; Thi Thu Nguyen, T.; Kambayashi, Y.; Miyagi, S.; Yamada, Y.; Suzuki, K.; Shimizu, Y.; Nakamura, H. Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels. Nutrients 2018, 10, 1825.
Nakamura H, Hara A, Tsujiguchi H, Thi Thu Nguyen T, Kambayashi Y, Miyagi S, Yamada Y, Suzuki K, Shimizu Y, Nakamura H. Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels. Nutrients. 2018; 10(12):1825.Chicago/Turabian Style
Nakamura, Haruki; Hara, Akinori; Tsujiguchi, Hiromasa; Thi Thu Nguyen, Thao; Kambayashi, Yasuhiro; Miyagi, Sakae; Yamada, Yohei; Suzuki, Keita; Shimizu, Yukari; Nakamura, Hiroyuki. 2018. "Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels." Nutrients 10, no. 12: 1825.
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