Next Article in Journal
Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels
Next Article in Special Issue
Probiotics on Pediatric Functional Gastrointestinal Disorders
Previous Article in Journal
College Students and Eating Habits: A Study Using An Ecological Model for Healthy Behavior
Previous Article in Special Issue
A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet

Probiotics in Celiac Disease

Paediatric Department, “SS Annunziata” Hospital, 74100 Taranto, Italy
Department of Paediatrics, Paediatric Hospital Giovanni XXIII, Via Amendola 207, 70126 Bari, Italy
Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, 70126 Bari, Italy
Pediatric Section, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 1824;
Received: 30 September 2018 / Revised: 6 November 2018 / Accepted: 15 November 2018 / Published: 23 November 2018
(This article belongs to the Special Issue Probiotics and Prebiotics in Pediatrics)
Recently, the interest in the human microbiome and its interplay with the host has exploded and provided new insights on its role in conferring host protection and regulating host physiology, including the correct development of immunity. However, in the presence of microbial imbalance and particular genetic settings, the microbiome may contribute to the dysfunction of host metabolism and physiology, leading to pathogenesis and/or the progression of several diseases. Celiac disease (CD) is a chronic autoimmune enteropathy triggered by dietary gluten exposure in genetically predisposed individuals. Despite ascertaining that gluten is the trigger in CD, evidence has indicated that intestinal microbiota is somehow involved in the pathogenesis, progression, and clinical presentation of CD. Indeed, several studies have reported imbalances in the intestinal microbiota of patients with CD that are mainly characterized by an increased abundance of Bacteroides spp. and a decrease in Bifidobacterium spp. The evidence that some of these microbial imbalances still persist in spite of a strict gluten-free diet and that celiac patients suffering from persistent gastrointestinal symptoms have a desert gut microbiota composition further support its close link with CD. All of this evidence gives rise to the hypothesis that probiotics might play a role in this condition. In this review, we describe the recent scientific evidences linking the gut microbiota in CD, starting from the possible role of microbes in CD pathogenesis, the attempt to define a microbial signature of disease, the effect of a gluten-free diet and host genetic assets regarding microbial composition to end in the exploration of the proof of concept of probiotic use in animal models to the most recent clinical application of selected probiotic strains. View Full-Text
Keywords: probiotics; microbiota; celiac disease; gluten free diet probiotics; microbiota; celiac disease; gluten free diet
Show Figures

Figure 1

MDPI and ACS Style

Cristofori, F.; Indrio, F.; Miniello, V.L.; De Angelis, M.; Francavilla, R. Probiotics in Celiac Disease. Nutrients 2018, 10, 1824.

AMA Style

Cristofori F, Indrio F, Miniello VL, De Angelis M, Francavilla R. Probiotics in Celiac Disease. Nutrients. 2018; 10(12):1824.

Chicago/Turabian Style

Cristofori, Fernanda, Flavia Indrio, Vito Leonardo Miniello, Maria De Angelis, and Ruggiero Francavilla. 2018. "Probiotics in Celiac Disease" Nutrients 10, no. 12: 1824.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop