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Nutrients 2018, 10(11), 1659; https://doi.org/10.3390/nu10111659

Preventive Effect of Garlic Oil and Its Organosulfur Component Diallyl-Disulfide on Cigarette Smoke-Induced Airway Inflammation in Mice

1
College of Veterinary Medicine (BK21 Plus Project Team), Chonnam National University, 27 Yongbong-ro, Buk-gu, Gwangju 61186, Korea
2
Namhae Garlic Research Institute, 2465-8 Namhae-daero, Namhae-gun, Gyungnam 52430, Korea
3
Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea
4
Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 177 Geonjae-ro, Naju-si, Jeollanam-do 58245, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 18 September 2018 / Revised: 31 October 2018 / Accepted: 1 November 2018 / Published: 4 November 2018
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Abstract

Garlic (Allium sativum) has traditionally been used as a medicinal food and exhibits various beneficial activities, such as antitumor, antimicrobial, hypolipidemic, antiarthritic, and hypoglycemic activities. The aim of this study was to explore the preventive effect of garlic oil (GO) and its organosulfur component diallyl disulfide (DADS) on cigarette smoke (CS)-induced airway inflammation. Mice were exposed to CS daily for 1 h (equivalent to eight cigarettes per day) for two weeks, and intranasally instilled with lipopolysaccharide (LPS) on day 12 after the initiation of CS exposure. GO and DADS were administered to mice by oral gavage, both at rates of 20 and 40 mg/kg, for 1 h before CS exposure for two weeks. In the bronchoalveolar lavage fluid, GO and DADS inhibited the elevation in the counts of inflammatory cells, particularly neutrophils, which were induced in the CS and LPS (CS + LPS) group. This was accompanied by the lowered production (relative to the CS + LPS group) of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. Histologically, GO and DADS inhibited the CS- and LPS-induced infiltration of inflammatory cells into lung tissues. Additionally, GO and DADS inhibited the phosphorylation of extracellular signal-regulated kinase and the expression of matrix metalloproteinase-9 in the lung tissues. Taken together, these findings indicate that GO and DADS could be a potential preventive agent in CS-induced airway inflammation. View Full-Text
Keywords: garlic oil; diallyl disulfide; cigarette smoke; airway inflammation; extracellular signal-regulated kinase; matrix metalloproteinase-9 garlic oil; diallyl disulfide; cigarette smoke; airway inflammation; extracellular signal-regulated kinase; matrix metalloproteinase-9
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Ko, J.-W.; Jeong, S.-H.; Kwon, H.-J.; Shin, N.-R.; Seo, Y.-S.; Kim, J.-C.; Shin, I.-S.; Kim, J.-S. Preventive Effect of Garlic Oil and Its Organosulfur Component Diallyl-Disulfide on Cigarette Smoke-Induced Airway Inflammation in Mice. Nutrients 2018, 10, 1659.

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