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Fatigue as an Extra-Intestinal Manifestation of Celiac Disease: A Systematic Review

Department of Health Science, Østfold University College, N-1757 Halden, Norway
Department of Gastroenterology, Østfold Hospital Trust Kalnes, N-1714 Grålum, Norway
Department of Research and Innovation, Vestfold Hospital Trust, N-3103 Tønsberg, Norway
Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, N-0318 Oslo, Norway
K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, N-0318 Oslo, Norway
Department of gastroenterology, Oslo University Hospital Rikshospitalet, N-0372 Oslo, Norway
Author to whom correspondence should be addressed.
Nutrients 2018, 10(11), 1652;
Received: 28 September 2018 / Revised: 24 October 2018 / Accepted: 26 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Extraintestinal Manifestations of Coeliac Disease)
PDF [562 KB, uploaded 3 November 2018]


Celiac disease may present with a range of different symptoms, including abdominal problems in a broader sense, iron deficiency and “constant tiredness”. All of these symptoms should consequently lead the clinicians to consider celiac disease as a potential etiopathogenetic cause. Although the pathophysiology of celiac disease is well documented, the actual mechanisms for disease presentation(s) are less well understood. We here address the topic of fatigue in celiac disease. A systematic literature search identified 298 papers of which five met the criteria for full evaluation. None of the reviewed papers were of high quality and had several methodological weaknesses. We conclude that there is an unmet need to study the contributing factors and management of fatigue in celiac disease. View Full-Text
Keywords: fatigue; energy; celiac disease; extra-intestinal manifestations fatigue; energy; celiac disease; extra-intestinal manifestations

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Jelsness-Jørgensen, L.-P.; Bernklev, T.; Lundin, K.E.A. Fatigue as an Extra-Intestinal Manifestation of Celiac Disease: A Systematic Review. Nutrients 2018, 10, 1652.

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