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Nutrients 2018, 10(11), 1651; https://doi.org/10.3390/nu10111651

Resveratrol, Metabolic Syndrome, and Gut Microbiota

1
Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
2
INSERM U1048, Institute of Metabolic and Cardiovascular Diseases (I2MC) and University Paul Sabatier, 31432 Toulouse, France
3
Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, 07122 Palma, Spain
4
Balearic Islands Health Research Institute (IdISBa), 07122 Palma, Spain
*
Authors to whom correspondence should be addressed.
Received: 15 October 2018 / Revised: 27 October 2018 / Accepted: 29 October 2018 / Published: 3 November 2018
(This article belongs to the Special Issue Benefits of Resveratrol Supplementation)
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Abstract

Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic syndrome-related alterations in experimental animals, including glucose and lipid homeostasis improvement and a reduction in fat mass, blood pressure, low-grade inflammation, and oxidative stress. Clinical trials have been carried out to address its potential; however, results are still inconclusive. Even though resveratrol is partly metabolized by gut microbiota, the relevance of this “forgotten organ” had not been widely considered. However, in the past few years, data has emerged suggesting that the therapeutic potential of this compound may be due to its interaction with gut microbiota, reporting changes in bacterial composition associated with beneficial metabolic outcomes. Even though data is still scarce and for the most part observational, it is promising nevertheless, suggesting that resveratrol supplementation could be a useful tool for the treatment of metabolic syndrome and its associated conditions. View Full-Text
Keywords: resveratrol; gut microbiota; metabolic syndrome resveratrol; gut microbiota; metabolic syndrome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Chaplin, A.; Carpéné, C.; Mercader, J. Resveratrol, Metabolic Syndrome, and Gut Microbiota. Nutrients 2018, 10, 1651.

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