Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Atrial and Adipose Tissue Samples
2.3. Preparation of Atrial Tissue Samples
2.4. Preparation of Adipose Tissue Samples
2.5. Analysis of Fatty Acid Composition in Adipose Tissue and Atrial Tissue
2.6. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Variables | n = 49 |
---|---|
Age, years | 66.0 (10.4) |
Men:Women | 39:10 |
Weight, kg | 81.1 (13.6) |
BMI, kg/m2 | 26.9 (3.7) |
Current smoking | 32 (65.3%) |
Prior MI | 9 (18.37%) |
Hypertension | 34 (69.4%) |
Diabetes mellitus | 12 (24.5%) |
EAT | PAT | SCAT | Atrium | |
---|---|---|---|---|
Total SFA | 31.05 (2.64) | 30.84 (2.55) | 30.18 (2.60) | 43.61 (2.22) |
14:0 (myristic acid) | 2.58 (0.52) | 2.83 (0.56) | 2.66 (0.53) | 0.99 (0.22) |
16:0 (palmitic acid) | 23.31 (1.92) | 22.62 (2.07) | 22.68 (2.08) | 34.35 (2.05) |
18:0 (stearic acid) | 5.17 (1.17) | 5.39 (0.97) | 4.84 (0.93) | 8.27 (0.70) |
Total MUFA | 45.70 (2.27) | 46.36 (2.23) | 46.96 (2.27) | 16.09 (1.82) |
18:1 n-9 (oleic acid) | 45.57 (2.27) | 46.24 (2.24) | 46.85 (2.27) | 16.04 (1.81) |
Total n-3 PUFA | 1.74 (0.38) | 1.59 (0.34) | 1.56 (0.31) | 5.40 (0.99) |
18:3 n-3 (ALA) | 0.89 (0.23) | 0.97 (0.26) | 0.94 (0.23) | 0.26 (0.07) |
20:5 n-3 (EPA) | 0.09 (0.03) | 0.08 (0.03) | 0.08 (0.03) | 0.84 (0.32) |
22:5 n-3 (DPA) | 0.37 (0.14) | 0.29 (0.13) | 0.31 (0.14) | 1.24 (0.24) |
22:6 n-3 (DHA) | 0.39 (0.18) | 0.26 (0.12) | 0.23 (0.11) | 3.07 (0.73) |
Total n-6 PUFA | 9.38 (1.43) | 9.58 (1.51) | 9.79 (1.47) | 26.80 (2.90) |
18:2 n-6 (LA) | 8.96 (1.41) | 9.30 (1.51) | 9.44 (1.45) | 12.07 (1.68) |
20:4 n-6 (AA) | 0.42 (0.13) | 0.28 (0.09) | 0.34 (0.13) | 14.73 (2.64) |
PAT vs. SCAT | EAT vs. SCAT | EAT vs. PAT | Global Test | |
---|---|---|---|---|
Total n-3 PUFA | 0.05 (0.02–0.08) | 0.12 (0.08–0.16) | 0.07 (0.02–0.12) | p < 0.001 |
18:3 n-3 (ALA) | 0.03 (0.01–0.05) | −0.05 (−0.08–−0.02) | −0.08 (−0.11–− 0.05) | p < 0.001 |
20:5 n-3 (EPA) | −0.01 (−0.01–−0.00) | 0.01 (0.00–0.01) | 0.01 (0.01–0.02) | p < 0.001 |
22:6 n-3 (DHA) | 0.03 (0.01–0.05) | 0.16 (0.13–0.19) | 0.13 (0.10–0.17) | p < 0.001 |
Total n-6 PUFA | −0.21 (−0.29–−0.13) | −0.41 (−0.54–−0.27) | −0.20 (−0.34–−0.05) | p < 0.001 |
18:2 n-6 (LA) | −0.15 (−0.22–−0.08) | −0.49 (−0.63–−0.35) | −0.34 (−0.49–−0.19) | p < 0.001 |
20:4 n-6 (AA) | −0.06 (−0.09–−0.04) | 0.08 (0.06–0.11) | 0.15 (0.12–0.18) | p < 0.001 |
Atrium vs. EAT | |
---|---|
Total n-3 PUFA | 2.79 (2.54–3.04) |
18:3 n-3 (ALA) | −0.63 (−0.68–0.58) |
20:5 n-3 (EPA) | 0.74 (0.66–0.83) |
22:6 n-3 (DHA) | 2.68 (2.48–2.87) |
Total n-6 PUFA | 17.42 (16.70–18.13) |
18:2 n-6 (LA) | 3.11 (2.67–3.55) |
20:4 n-6 (AA) | 14.31 (13.60–15.01) |
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Hjelmgaard, K.; Eschen, R.B.; Schmidt, E.B.; Andreasen, J.J.; Lundbye-Christensen, S. Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue. Nutrients 2018, 10, 1506. https://doi.org/10.3390/nu10101506
Hjelmgaard K, Eschen RB, Schmidt EB, Andreasen JJ, Lundbye-Christensen S. Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue. Nutrients. 2018; 10(10):1506. https://doi.org/10.3390/nu10101506
Chicago/Turabian StyleHjelmgaard, Katrin, Rikke B. Eschen, Erik B. Schmidt, Jan J. Andreasen, and Søren Lundbye-Christensen. 2018. "Fatty Acid Composition in Various Types of Cardiac Adipose Tissues and Its Relation to the Fatty Acid Content of Atrial Tissue" Nutrients 10, no. 10: 1506. https://doi.org/10.3390/nu10101506