Next Article in Journal
Serum Carotenoids Reveal Poor Fruit and Vegetable Intake among Schoolchildren in Burkina Faso
Next Article in Special Issue
Adherence to Gluten-Free Diet in Children with Celiac Disease
Previous Article in Journal
Stunting, Beyond Acute Diarrhoea: Giardia Duodenalis, in Cambodia
Previous Article in Special Issue
Social and Emotional Fears and Worries Influencing the Quality of Life of Female Celiac Disease Patients Following a Gluten-Free Diet
Open AccessReview

The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others

Instituto de Investigaciones Medico Biológicas, Universidad Veracruzana, Calle Agustín de Iturbide, Salvador Díaz Mirón, Veracruz 91700, Mexico
Department of Nutrition and Food Science, Texas A&M University, 2253 TAMU, College Station, TX 77843, USA
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1421;
Received: 27 August 2018 / Revised: 25 September 2018 / Accepted: 1 October 2018 / Published: 4 October 2018
(This article belongs to the Special Issue Gluten-Free Diet)
Gluten-related disorders (GRD) affect millions of people worldwide and have been related to the composition and metabolism of the gut microbiota. These disorders present differently in each patient and the only treatment available is a strict life-long gluten-free diet (GFD). Several studies have investigated the effect of a GFD on the gut microbiota of patients afflicted with GRD as well as healthy people. The purpose of this review is to persuade the biomedical community to think that, while useful, the results from the effect of GFD on health and the gut microbiota cannot be extrapolated from one population to others. This argument is primarily based on the highly individualized pattern of gut microbial composition and metabolic activity in each person, the variability of the gut microbiota over time and the plethora of factors associated with this variation. In addition, there is wide variation in the composition, economic viability, and possible deleterious effects to health among different GFD, both within and among countries. Overall, this paper encourages the conception of more collaborative efforts to study local populations in an effort to reach biologically and medically useful conclusions that truly contribute to improve health in patients afflicted with GRD. View Full-Text
Keywords: celiac disease; gluten-free diet; gut microbiota celiac disease; gluten-free diet; gut microbiota
Show Figures

Graphical abstract

MDPI and ACS Style

Garcia-Mazcorro, J.F.; Noratto, G.; Remes-Troche, J.M. The Effect of Gluten-Free Diet on Health and the Gut Microbiota Cannot Be Extrapolated from One Population to Others. Nutrients 2018, 10, 1421.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop