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Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling

Department of Food Science and Biotechnology, College of Life Science, CHA University, 463–400 Seongnam, Kyonggi, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(1), 51; https://doi.org/10.3390/nu10010051
Received: 24 October 2017 / Revised: 29 December 2017 / Accepted: 5 January 2018 / Published: 6 January 2018
Gelidium elegans, a red alga native to the Asia Pacific region, contains biologically active polyphenols. We conducted a molecular biological study of the anti-diabetic effect of Gelidium elegans extract (GEE) in C57BL/KsJ-db/db mice. Mice that had been administered GEE had significantly lower body mass, water consumption, and fasting blood glucose than db/db controls. Moreover, hemoglobin A1c (HbA1c), an indicator of the glycemic status of people with diabetes, was significantly lower in mice that had been administered GEE. We also found that 200 mg/kg/day GEE upregulates the insulin signaling pathway by activating insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K), and increasing the expression of glucose transporter type 4 (GLUT4). In parallel, mitogen-activated protein kinase (MAPK) activity was lower in GEE-treated groups. In summary, these findings indicate that GEE regulates glucose metabolism by activating the insulin signaling pathway and downregulating the MAPK signaling pathway. View Full-Text
Keywords: Gelidium elegans extract; type 2 diabetes; diabetic symptoms; glucose uptake; MAPK pathways; AKT Gelidium elegans extract; type 2 diabetes; diabetic symptoms; glucose uptake; MAPK pathways; AKT
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Choi, J.; Kim, K.-J.; Koh, E.-J.; Lee, B.-Y. Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling. Nutrients 2018, 10, 51.

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