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Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice

Department of Nutrition, The University of Tennessee, Knoxville, TN 37996-1920, USA
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Nutrients 2009, 1(1), 50-70; https://doi.org/10.3390/nu1010050
Received: 9 July 2009 / Accepted: 10 August 2009 / Published: 14 August 2009
(This article belongs to the Special Issue Obesity, Nutrition and Dietetics)
Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice. View Full-Text
Keywords: aging; lifespan; oxidative stress; inflammatory stress; dietary calcium; dairy aging; lifespan; oxidative stress; inflammatory stress; dietary calcium; dairy
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MDPI and ACS Style

Bruckbauer, A.; Zemel, M.B. Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice. Nutrients 2009, 1, 50-70. https://doi.org/10.3390/nu1010050

AMA Style

Bruckbauer A, Zemel MB. Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice. Nutrients. 2009; 1(1):50-70. https://doi.org/10.3390/nu1010050

Chicago/Turabian Style

Bruckbauer, Antje, and Michael B. Zemel. 2009. "Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice" Nutrients 1, no. 1: 50-70. https://doi.org/10.3390/nu1010050

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