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Article

Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer—An Exploratory Analysis in Western Romania

1
Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania
2
Research Center for Pharmaco-Toxicological Evaluations, Faculty of Pharmacy, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
3
Department of Dental Aesthetics, Faculty of Dental Medicine, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
4
Department of Nephrology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
5
Department of ENT, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
6
Department of Functional Sciences–Pathophysiology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
7
Centre for Translational Research and Systems Medicine, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
8
Department of Hematology, “Victor Babeș” University of Medicine and Pharmacy, 300041 Timișoara, Romania
9
Department of Pharmaceutical Technology, Faculty of Pharmacy, “Vasile Goldiș” Western University, 86 Liviu Rebreanu, 310045 Arad, Romania
*
Author to whom correspondence should be addressed.
Clin. Pract. 2024, 14(4), 1270-1284; https://doi.org/10.3390/clinpract14040103
Submission received: 4 April 2024 / Revised: 15 June 2024 / Accepted: 26 June 2024 / Published: 29 June 2024
(This article belongs to the Special Issue Clinical Outcome Research in the Head and Neck)

Abstract

Background: Diagnosis and treatment for pharyngeal cancer are decisive in determining prognosis. Diagnosis delays are frequent, representing a significant cause of avoidable mortality, and an important factor in subpar survival across the continuous HNC care delivery. Methods: The present study represents a retrospective analysis of medical records from Western Romania, which included 180 patients, to evaluate the impact of time-to-treatment delay on patients diagnosed with pharyngeal cancer. The data analyses were performed using the Kaplan–Meier method R (version 3.6.3) packages, including tidyverse, final-fit, mcgv, survival, stringdist, janitor, and Hmisc. Results: The mean days from diagnosis until the end of treatment were higher for the nasopharynx group. Cox regression analysis regarding diagnosis to treatment duration categories showed an increased risk mortality by 3.11 times (95%CI: 1.51–6.41, p = 0.0021) with a Harrell’s C-index of 0.638 (95%CI: 0.552–0.723). The hypopharynx and oropharynx locations increased risk mortality by 4.59 (95%CI: 1.55–13.55) and 5.49 times (95%CI: 1.79–16.81) compared to the nasopharynx location. Conclusions: The findings of this study led to the conclusion that it seems there is a trend of mortality risk for oropharynx and hypopharynx cancers due to delays in the time to treatment over 70 days, standing as a basis for further research as there is an imperative need for prospective multicenter studies.
Keywords: time to treatment; pharyngeal cancer; overall survival; delayed diagnosis time to treatment; pharyngeal cancer; overall survival; delayed diagnosis

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MDPI and ACS Style

Kiș, A.M.; Buzatu, R.; Chisavu, L.; Poenaru, M.; Borza, C.; Iftode, A.; Sarau, O.S.; Dehelean, C.A.; Ardelean, S. Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer—An Exploratory Analysis in Western Romania. Clin. Pract. 2024, 14, 1270-1284. https://doi.org/10.3390/clinpract14040103

AMA Style

Kiș AM, Buzatu R, Chisavu L, Poenaru M, Borza C, Iftode A, Sarau OS, Dehelean CA, Ardelean S. Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer—An Exploratory Analysis in Western Romania. Clinics and Practice. 2024; 14(4):1270-1284. https://doi.org/10.3390/clinpract14040103

Chicago/Turabian Style

Kiș, Andreea Mihaela, Roxana Buzatu, Lazar Chisavu, Marioara Poenaru, Claudia Borza, Andrada Iftode, Oana Silvana Sarau, Cristina Adriana Dehelean, and Simona Ardelean. 2024. "Time-to-Treatment Delays and Their Prognostic Implications in Pharyngeal Cancer—An Exploratory Analysis in Western Romania" Clinics and Practice 14, no. 4: 1270-1284. https://doi.org/10.3390/clinpract14040103

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