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Article

Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study

by
Antonio Gidaro
1,*,
Alessandro Palmerio Delitala
2,
Roberto Manetti
2,
Sonia Caccia
1,
Mark J. Soloski
3,
Giorgio Lambertenghi Deliliers
4,
Dante Castro
2,
Mattia Donadoni
1,
Arianna Bartoli
1,
Giuseppe Sanna
2,
Luigi Bergamaschini
1 and
Roberto Castelli
2,*
1
Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan, Via G.B. Grassi N° 74, 20157 Milan, Italy
2
Department of Medicine, Surgery and Pharmacy University of Sassari, Via San Pietro 43, 07100 Sassari, Italy
3
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
4
Fondazione Mattarelli Largo della Crocetta, N° 2, 20122 Milan, Italy
*
Authors to whom correspondence should be addressed.
Hematol. Rep. 2023, 15(4), 684-695; https://doi.org/10.3390/hematolrep15040069
Submission received: 18 July 2023 / Revised: 31 August 2023 / Accepted: 29 November 2023 / Published: 4 December 2023
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Congenital and Acquired Haemorrhagic Disorders, Thromboembolic Disease and Platelet Disorders)
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Abstract

Background: Platelet “Microvesicles” (MVs) are studied for their role in blood coagulation and inflammation. The study aimed to establish if MVs are related to age, plasma levels of inflammation, coagulation, and fibrinolysis markers in healthy individuals. Methods: We prospectively enrolled volunteers aged over 18 years. MVs, plasma levels of C-reactive protein (CRP), Interleukin 6 (IL-6), Interleukin 10 (IL-10), Interleukin 17 (IL-17), and transforming growth factor β (TGF-β), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (VWF), homocysteine, factor VII (FVII), thrombin activatable fibrinolysis inhibitor (TAFI), and Protein S were tested. Results: A total of 246 individuals (median age 65 years (“IQR”54–72)) were evaluated. Both univariate analysis and logistic regression models showed that MVs positively correlate with age, CRP, IL-6, IL-10, IL-17, TGF-β, fibrinogen, PAI-1, VWF, FVII, and homocysteine, while inversely correlating with TAFI and Protein S. The ROC curve analysis performed to identify a cut off for MV values (700 kMP) showed a good accuracy with over-range cytokines fibrinolysis factor and coagulation markers. Conclusions: To the best of our knowledge, this study is the first to correlate MVs with an entire panel of cardiovascular risk factors in healthy individuals. A future possible role of MVs in screening exams is suggested.
Keywords: microvesicles; microparticles; C-reactive protein (CRP); Interleukin 6 (IL-6); Interleukin 10 (IL-10); Interleukin 17 (IL-17); transforming growth factor β (TGF-β); fibrinogen; plasminogen activator inhibitor-1 (PAI-1); von Willebrand factor (VWF); homocysteine; thrombin activatable fibrinolysis inhibitor (TAFI); factor VII (FVII); Protein S microvesicles; microparticles; C-reactive protein (CRP); Interleukin 6 (IL-6); Interleukin 10 (IL-10); Interleukin 17 (IL-17); transforming growth factor β (TGF-β); fibrinogen; plasminogen activator inhibitor-1 (PAI-1); von Willebrand factor (VWF); homocysteine; thrombin activatable fibrinolysis inhibitor (TAFI); factor VII (FVII); Protein S

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MDPI and ACS Style

Gidaro, A.; Delitala, A.P.; Manetti, R.; Caccia, S.; Soloski, M.J.; Lambertenghi Deliliers, G.; Castro, D.; Donadoni, M.; Bartoli, A.; Sanna, G.; et al. Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study. Hematol. Rep. 2023, 15, 684-695. https://doi.org/10.3390/hematolrep15040069

AMA Style

Gidaro A, Delitala AP, Manetti R, Caccia S, Soloski MJ, Lambertenghi Deliliers G, Castro D, Donadoni M, Bartoli A, Sanna G, et al. Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study. Hematology Reports. 2023; 15(4):684-695. https://doi.org/10.3390/hematolrep15040069

Chicago/Turabian Style

Gidaro, Antonio, Alessandro Palmerio Delitala, Roberto Manetti, Sonia Caccia, Mark J. Soloski, Giorgio Lambertenghi Deliliers, Dante Castro, Mattia Donadoni, Arianna Bartoli, Giuseppe Sanna, and et al. 2023. "Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study" Hematology Reports 15, no. 4: 684-695. https://doi.org/10.3390/hematolrep15040069

APA Style

Gidaro, A., Delitala, A. P., Manetti, R., Caccia, S., Soloski, M. J., Lambertenghi Deliliers, G., Castro, D., Donadoni, M., Bartoli, A., Sanna, G., Bergamaschini, L., & Castelli, R. (2023). Platelet Microvesicles, Inflammation, and Coagulation Markers: A Pilot Study. Hematology Reports, 15(4), 684-695. https://doi.org/10.3390/hematolrep15040069

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