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Microbiology Research
Volume 17
Issue 2
10.3390/microbiolres17020029
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Article

Use of Daptomycin for the Treatment of Infective Endocarditis Due to Methicillin-Susceptible Staphylococcus aureus (MSSA): A Multicenter Retrospective Study

by
Andrea Tommasi
1,†,
Cesare Bolla
2,
Laura Curci
1,
Serena Penpa
3,
Giovanni Genga
1,
Cristina Sarda
2,
Elisabetta Svizzeretto
1,
Andrea Salvaderi
4,
Giorgia Piceni
3,
Giuseppe Vittorio De Socio
1,
Daniela Francisci
1,‡ on behalf of the LEIOT Study Group,
Antonio Maconi
3,
Guido Chichino
2 and
Carlo Pallotto
1,*,†
1
Infectious Diseases Clinic, Santa Maria della Misericordia Hospital, University of Perugia, 06100 Perugia, Italy
2
Infectious Diseases, Department of Internal Medicine, Azienda Ospedaliera-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15100 Alessandria, Italy
3
Research Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliera-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15100 Alessandria, Italy
4
Infectious Diseases Clinic, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Membership of the Group Name is provided in the Acknowledgments.
Microbiol. Res. 2026, 17(2), 29; https://doi.org/10.3390/microbiolres17020029
Submission received: 15 November 2025 / Revised: 9 January 2026 / Accepted: 20 January 2026 / Published: 23 January 2026
Versions Notes

Abstract

Infective endocarditis (IE) due to methicillin-susceptible Staphylococcus aureus (MSSA) still represents a clinical and therapeutic issue. Discrepancies between guidelines, clinical studies and clinical practice have already been highlighted, especially regarding daptomycin use in MSSA cases. The aim of this study was to evaluate daptomycin’s impact on outcomes in this setting. This was a retrospective observational study. We enrolled all patients with MSSA IE admitted from 2015 to 2023. Patients were divided into two groups according to daptomycin administration. We enrolled 76 patients, with 49 in group A (standard treatment) and 27 in group B (treated with daptomycin). The in-hospital crude mortality was 14.3% and 29.6% in group A and B, respectively (p = 0.191). Only heart failure was significantly associated with negative outcome in the univariate and multivariate analyses (OR 6.424, 95% CI, 1.680–24.559; p = 0.007). In this study population, daptomycin treatment for IE due to MSSA was not associated with a reduced mortality rate. Heart failure was the only independent risk factor associated with in-hospital mortality.
Keywords: endocarditis; Staphylococcus aureus; MSSA; daptomycin; guidelines endocarditis; Staphylococcus aureus; MSSA; daptomycin; guidelines

Share and Cite

MDPI and ACS Style

Tommasi, A.; Bolla, C.; Curci, L.; Penpa, S.; Genga, G.; Sarda, C.; Svizzeretto, E.; Salvaderi, A.; Piceni, G.; De Socio, G.V.; et al. Use of Daptomycin for the Treatment of Infective Endocarditis Due to Methicillin-Susceptible Staphylococcus aureus (MSSA): A Multicenter Retrospective Study. Microbiol. Res. 2026, 17, 29. https://doi.org/10.3390/microbiolres17020029

AMA Style

Tommasi A, Bolla C, Curci L, Penpa S, Genga G, Sarda C, Svizzeretto E, Salvaderi A, Piceni G, De Socio GV, et al. Use of Daptomycin for the Treatment of Infective Endocarditis Due to Methicillin-Susceptible Staphylococcus aureus (MSSA): A Multicenter Retrospective Study. Microbiology Research. 2026; 17(2):29. https://doi.org/10.3390/microbiolres17020029

Chicago/Turabian Style

Tommasi, Andrea, Cesare Bolla, Laura Curci, Serena Penpa, Giovanni Genga, Cristina Sarda, Elisabetta Svizzeretto, Andrea Salvaderi, Giorgia Piceni, Giuseppe Vittorio De Socio, and et al. 2026. "Use of Daptomycin for the Treatment of Infective Endocarditis Due to Methicillin-Susceptible Staphylococcus aureus (MSSA): A Multicenter Retrospective Study" Microbiology Research 17, no. 2: 29. https://doi.org/10.3390/microbiolres17020029

APA Style

Tommasi, A., Bolla, C., Curci, L., Penpa, S., Genga, G., Sarda, C., Svizzeretto, E., Salvaderi, A., Piceni, G., De Socio, G. V., Francisci, D., on behalf of the LEIOT Study Group, Maconi, A., Chichino, G., & Pallotto, C. (2026). Use of Daptomycin for the Treatment of Infective Endocarditis Due to Methicillin-Susceptible Staphylococcus aureus (MSSA): A Multicenter Retrospective Study. Microbiology Research, 17(2), 29. https://doi.org/10.3390/microbiolres17020029

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