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Review

Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease

1
Adult Congenital Heart Disease Unit, AO dei Colli—Monaldi Hospital, 80131 Naples, Italy
2
Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Monaldi Hospital, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Matteo Vattaand and George E. Louridas
Cardiogenetics 2022, 12(2), 170-184; https://doi.org/10.3390/cardiogenetics12020016
Received: 20 December 2021 / Revised: 11 March 2022 / Accepted: 28 March 2022 / Published: 1 April 2022
(This article belongs to the Special Issue Cardiogenetics: Feature Papers 2021)
Left ventricular non-compaction (LVNC) is an extremely heterogeneous disorder with a highly variable clinical presentation, morphologic appearance at imaging testing, and prognosis. It is still unclear whether LVNC should be classified as a separate cardiomyopathy or if it is a mere morphological trait shared by many phenotypically distinct cardiomyopathies. Moreover, the hypertrabeculated phenotype may be reversible in some cases, possibly reflecting the left ventricular physiological response of the cardiac muscle to chronic overload. The current diagnostic criteria have several limitations, leaving many patients in a grey area. Here, we review the available literature on LVNC in order to provide an overview of the current knowledge on this complex disorder. View Full-Text
Keywords: left ventricular non-compaction; LVNC; hypertrabeculated left ventricle; cardiomyopathy; reversible left ventricular non-compaction; LVNC; hypertrabeculated left ventricle; cardiomyopathy; reversible
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MDPI and ACS Style

Fusco, F.; Borrelli, N.; Barracano, R.; Ciriello, G.D.; Verrillo, F.; Scognamiglio, G.; Sarubbi, B. Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease. Cardiogenetics 2022, 12, 170-184. https://doi.org/10.3390/cardiogenetics12020016

AMA Style

Fusco F, Borrelli N, Barracano R, Ciriello GD, Verrillo F, Scognamiglio G, Sarubbi B. Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease. Cardiogenetics. 2022; 12(2):170-184. https://doi.org/10.3390/cardiogenetics12020016

Chicago/Turabian Style

Fusco, Flavia, Nunzia Borrelli, Rosaria Barracano, Giovanni D. Ciriello, Federica Verrillo, Giancarlo Scognamiglio, and Berardo Sarubbi. 2022. "Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease" Cardiogenetics 12, no. 2: 170-184. https://doi.org/10.3390/cardiogenetics12020016

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