Next Article in Journal
Left Ventricular Non-Compaction Spectrum in Adults and Children: From a Morphological Trait to a Structural Muscular Disease
Previous Article in Journal
Pancarditis as the Clinical Presentation of Eosinophilic Granulomatosis with Polyangiitis: A Multimodality Approach to Diagnosis
Review

Clinical Phenotypes of Cardiovascular and Heart Failure Diseases Can Be Reversed? The Holistic Principle of Systems Biology in Multifaceted Heart Diseases

1
Independent Researcher, 55236 Thessaloniki, Greece
2
Department of Cardiology, Aristotle University, 54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Limongelli
Cardiogenetics 2022, 12(2), 142-169; https://doi.org/10.3390/cardiogenetics12020015
Received: 11 January 2022 / Revised: 22 March 2022 / Accepted: 30 March 2022 / Published: 1 April 2022
Recent advances in cardiology and biological sciences have improved quality of life in patients with complex cardiovascular diseases (CVDs) or heart failure (HF). Regardless of medical progress, complex cardiac diseases continue to have a prolonged clinical course with high morbidity and mortality. Interventional coronary techniques together with drug therapy improve quality and future prospects of life, but do not reverse the course of the atherosclerotic process that remains relentlessly progressive. The probability of CVDs and HF phenotypes to reverse can be supported by the advances made on the medical holistic principle of systems biology (SB) and on artificial intelligence (AI). Studies on clinical phenotypes reversal should be based on the research performed in large populations of patients following gathering and analyzing large amounts of relative data that embrace the concept of complexity. To decipher the complexity conundrum, a multiomics approach is needed with network analysis of the biological data. Only by understanding the complexity of chronic heart diseases and explaining the interrelationship between different interconnected biological networks can the probability for clinical phenotypes reversal be increased. View Full-Text
Keywords: holistic thinking; reversal of complex diseases; cardiovascular disease; heart failure; prediction and prevention; systems biology holistic thinking; reversal of complex diseases; cardiovascular disease; heart failure; prediction and prevention; systems biology
Show Figures

Figure 1

MDPI and ACS Style

Lourida, K.G.; Louridas, G.E. Clinical Phenotypes of Cardiovascular and Heart Failure Diseases Can Be Reversed? The Holistic Principle of Systems Biology in Multifaceted Heart Diseases. Cardiogenetics 2022, 12, 142-169. https://doi.org/10.3390/cardiogenetics12020015

AMA Style

Lourida KG, Louridas GE. Clinical Phenotypes of Cardiovascular and Heart Failure Diseases Can Be Reversed? The Holistic Principle of Systems Biology in Multifaceted Heart Diseases. Cardiogenetics. 2022; 12(2):142-169. https://doi.org/10.3390/cardiogenetics12020015

Chicago/Turabian Style

Lourida, Katerina G., and George E. Louridas. 2022. "Clinical Phenotypes of Cardiovascular and Heart Failure Diseases Can Be Reversed? The Holistic Principle of Systems Biology in Multifaceted Heart Diseases" Cardiogenetics 12, no. 2: 142-169. https://doi.org/10.3390/cardiogenetics12020015

Find Other Styles

Article Access Map by Country/Region

1
Back to TopTop