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Article

Modified Body Mass Index as a Novel Nutritional and Prognostic Marker in Patients with Cardiac Amyloidosis

1
Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”—Monaldi Hospital, 80131 Naples, Italy
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Haematology Unit, Department of Clinical Medicine and Surgery, University Federico II, 80131 Naples, Italy
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Department of Neurosciences, Reproductive Sciences and Odontostomatology, University Federico II, 80131 Naples, Italy
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Heart Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
5
Institute of Cardiovascular Sciences, College of London and St. Bartholomew’s Hospital, London EC1A 7BE, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Matteo Vatta
Cardiogenetics 2022, 12(2), 185-197; https://doi.org/10.3390/cardiogenetics12020017
Received: 1 February 2022 / Revised: 26 March 2022 / Accepted: 6 April 2022 / Published: 13 April 2022
The nutritional assessment is gaining clinical relevance since cardiac cachexia and malnutrition are emerging as novel markers of functional status and prognosis in many cardiovascular disorders, including cardiac amyloidosis (CA). This study aimed to evaluate the prognostic role of different nutritional indices for cardiovascular mortality in patients with CA and subgroups. Fifty CA patients (26 AL and 24 ATTR wild-type) were retrospectively analyzed. All patients underwent a comprehensive clinical and laboratory evaluation. Conventional body mass index (cBMI), modified BMI (mBMI), new BMI (nBMI) and prognostic nutritional index (PNI) were analyzed. Multivariate regression analysis was performed to identify the association between nutritional and other clinical-laboratory parameters with cardiovascular death. Compared to ATTRwt patients, those with AL showed lower mBMI values. No significant difference was observed for the other nutritional indices. During a median follow-up of 11.2 months, a lower mBMI quartile was associated with worse survival, in both groups. In multivariate analysis, mBMI emerged as an independent predictor for cardiovascular death. This study showed that mBMI is a novel index of malnutrition and an independent risk factor for cardiovascular mortality in patients with CA in both AL and ATTRwt form. View Full-Text
Keywords: cardiac amyloidosis; nutritional indexes; prognosis cardiac amyloidosis; nutritional indexes; prognosis
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MDPI and ACS Style

Dongiglio, F.; Palmiero, G.; Monda, E.; Rubino, M.; Verrillo, F.; Caiazza, M.; Cirillo, A.; Fusco, A.; Vetrano, E.; Lioncino, M.; Diana, G.; Di Fraia, F.; Cerciello, G.; Manganelli, F.; Vriz, O.; Limongelli, G. Modified Body Mass Index as a Novel Nutritional and Prognostic Marker in Patients with Cardiac Amyloidosis. Cardiogenetics 2022, 12, 185-197. https://doi.org/10.3390/cardiogenetics12020017

AMA Style

Dongiglio F, Palmiero G, Monda E, Rubino M, Verrillo F, Caiazza M, Cirillo A, Fusco A, Vetrano E, Lioncino M, Diana G, Di Fraia F, Cerciello G, Manganelli F, Vriz O, Limongelli G. Modified Body Mass Index as a Novel Nutritional and Prognostic Marker in Patients with Cardiac Amyloidosis. Cardiogenetics. 2022; 12(2):185-197. https://doi.org/10.3390/cardiogenetics12020017

Chicago/Turabian Style

Dongiglio, Francesca, Giuseppe Palmiero, Emanuele Monda, Marta Rubino, Federica Verrillo, Martina Caiazza, Annapaola Cirillo, Adelaide Fusco, Erica Vetrano, Michele Lioncino, Gaetano Diana, Francesco Di Fraia, Giuseppe Cerciello, Fiore Manganelli, Olga Vriz, and Giuseppe Limongelli. 2022. "Modified Body Mass Index as a Novel Nutritional and Prognostic Marker in Patients with Cardiac Amyloidosis" Cardiogenetics 12, no. 2: 185-197. https://doi.org/10.3390/cardiogenetics12020017

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