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Analysis of ABC Transporter Gene Expression in Atherosclerosis

1
Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia
2
Department of Pharmacology and Pharmacy, Ryazan State Medical University, 390026 Ryazan, Russia
*
Author to whom correspondence should be addressed.
Cardiogenetics 2021, 11(4), 204-218; https://doi.org/10.3390/cardiogenetics11040021
Received: 27 September 2021 / Revised: 29 October 2021 / Accepted: 1 November 2021 / Published: 4 November 2021
ABC transporters are a large family of membrane proteins that transport chemically diverse substrates across the cell membrane. Disruption of transport mechanisms mediated by ABC transporters causes the development of various diseases, including atherosclerosis. Methods: A bioinformatic analysis of a dataset from Gene Expression Omnibus (GEO) was performed. A GEO dataset containing data on gene expression levels in samples of atherosclerotic lesions and control arteries without atherosclerotic lesions from carotid, femoral, and infrapopliteal arteries was used for analysis. To evaluate differentially expressed genes, a bioinformatic analysis was performed in comparison groups using the limma package in R (v. 4.0.2) and the GEO2R and Phantasus tools (v. 1.11.0). Results: The obtained data indicate the differential expression of many ABC transporters belonging to different subfamilies. The differential expressions of ABC transporter genes involved in lipid transport, mechanisms of multidrug resistance, and mechanisms of ion exchange are shown. Differences in the expression of transporters in tissue samples from different arteries are established. Conclusions: The expression of ABC transporter genes demonstrates differences in atherosclerotic samples and normal arteries, which may indicate the involvement of transporters in the pathogenesis of atherosclerosis. View Full-Text
Keywords: ABC transporters; atherosclerosis; gene expression; bioinformatic analysis ABC transporters; atherosclerosis; gene expression; bioinformatic analysis
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MDPI and ACS Style

Kotlyarov, S.; Kotlyarova, A. Analysis of ABC Transporter Gene Expression in Atherosclerosis. Cardiogenetics 2021, 11, 204-218. https://doi.org/10.3390/cardiogenetics11040021

AMA Style

Kotlyarov S, Kotlyarova A. Analysis of ABC Transporter Gene Expression in Atherosclerosis. Cardiogenetics. 2021; 11(4):204-218. https://doi.org/10.3390/cardiogenetics11040021

Chicago/Turabian Style

Kotlyarov, Stanislav, and Anna Kotlyarova. 2021. "Analysis of ABC Transporter Gene Expression in Atherosclerosis" Cardiogenetics 11, no. 4: 204-218. https://doi.org/10.3390/cardiogenetics11040021

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