pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis of SPHHs
2.3. Drying of SPHHs
2.4. Drug (Amoxicillin Trihydrate) Loading of SPHHs-AT
2.5. pH-Responsive Swelling of SPHHs-AT
2.6. Density of SPHHs
2.7. Gelation Kinetics of SPHHs
2.8. Mechanical Stability of SPHHs
2.9. SEM
2.10. FTIRATR, X- RD and DSC
2.11. Drug Content and In Vitro Drug Release
3. Results and Discussion
3.1. SPHHs and Swelling Studies
3.2. Density and Gelation Kinetics of SPHHs
3.3. Mechanical Performance of SPHHs
3.4. SPHHs’ Morphology
3.5. Comprehensive Study of SPHHs and SPHHs-AT
3.6. Drug Loading and Release Performance
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Juthi, A.Z.; Li, F.; Wang, B.; Alam, M.M.; Talukder, M.E.; Qiu, B. pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery. Pharmaceutics 2023, 15, 816. https://doi.org/10.3390/pharmaceutics15030816
Juthi AZ, Li F, Wang B, Alam MM, Talukder ME, Qiu B. pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery. Pharmaceutics. 2023; 15(3):816. https://doi.org/10.3390/pharmaceutics15030816
Chicago/Turabian StyleJuthi, Ajkia Zaman, Fenfen Li, Bo Wang, Md Mofasserul Alam, Md Eman Talukder, and Bensheng Qiu. 2023. "pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery" Pharmaceutics 15, no. 3: 816. https://doi.org/10.3390/pharmaceutics15030816