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Review

Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades

1
School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1010, New Zealand
2
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Marzia Cirri and Bozena B. Michniak-Kohn
Pharmaceutics 2022, 14(5), 1072; https://doi.org/10.3390/pharmaceutics14051072
Received: 31 March 2022 / Revised: 25 April 2022 / Accepted: 13 May 2022 / Published: 17 May 2022
(This article belongs to the Special Issue Strategies to Enhance Drug Permeability across Biological Barriers)
Application of modern delivery techniques to natural bioactive products improves their permeability, bioavailability, and therapeutic efficacy. Many natural products have desirable biological properties applicable to wound healing but are limited by their inability to cross the stratum corneum to access the wound. Over the past two decades, modern systems such as microneedles, lipid-based vesicles, hydrogels, composite dressings, and responsive formulations have been applied to natural products such as curcumin or aloe vera to improve their delivery and efficacy. This article reviews which natural products and techniques have been formulated together in the past two decades and the success of these applications for wound healing. Many cultures prefer natural-product-based traditional therapies which are often cheaper and more available than their synthetic counterparts. Improving natural products’ effect can provide novel wound-healing therapies for those who trust traditional compounds over synthetic drugs to reduce medical inequalities. View Full-Text
Keywords: wound healing; natural products; advanced delivery; traditional medicine; alternative medicine wound healing; natural products; advanced delivery; traditional medicine; alternative medicine
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MDPI and ACS Style

Ryall, C.; Duarah, S.; Chen, S.; Yu, H.; Wen, J. Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades. Pharmaceutics 2022, 14, 1072. https://doi.org/10.3390/pharmaceutics14051072

AMA Style

Ryall C, Duarah S, Chen S, Yu H, Wen J. Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades. Pharmaceutics. 2022; 14(5):1072. https://doi.org/10.3390/pharmaceutics14051072

Chicago/Turabian Style

Ryall, Cameron, Sanjukta Duarah, Shuo Chen, Haijun Yu, and Jingyuan Wen. 2022. "Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades" Pharmaceutics 14, no. 5: 1072. https://doi.org/10.3390/pharmaceutics14051072

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