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Pharmaceutics
Volume 14
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10.3390/pharmaceutics14030579
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Article

Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery

by
Daria Niewolik
1,*,
Barbara Bednarczyk-Cwynar
2,
Piotr Ruszkowski
3,
Alicja Kazek-Kęsik
4,5,
Grzegorz Dzido
6 and
Katarzyna Jaszcz
1
1
Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland
2
Department of Organic Chemistry, Poznan University of Medical Science, Grunwaldzka 6, 60-780 Poznan, Poland
3
Department of Pharmacology, Poznan University of Medical Science, Rokietnicka 5a, 60-806 Poznan, Poland
4
Department of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Silesian University of Technology, B. Krzywoustego 6, 44-100 Gliwice, Poland
5
Biotechnology Centre, Silesian University of Technology, B. Krzywoustego 8, 44-100 Gliwice, Poland
6
Department of Chemical Engineering and Process Design, Silesian University of Technology, M. Strzody 7, 44-100 Gliwice, Poland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2022, 14(3), 579; https://doi.org/10.3390/pharmaceutics14030579
Submission received: 18 January 2022 / Revised: 2 March 2022 / Accepted: 4 March 2022 / Published: 6 March 2022
(This article belongs to the Special Issue Biodegradable Polymers for Pharmaceutical Applications)
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Abstract

This paper describes the preparation and characterization of polymer-drug systems based on polymeric microspheres obtained from poly(betulin disuccinate-co-sebacic acid). The active compound that was coupled to the betulin-based carriers was rifampicin (RIF), an ansamycin drug used in the treatment of tuberculosis. Poly(betulin disuccinate-co-sebacic acid) microspheres were prepared using a solvent evaporation technique from copolymers obtained by polycondensation of betulin disuccinate (DBB) and sebacic acid (SEB). The content of sebacic acid in the copolymers was 20, 40, 60 and 80 wt%, respectively. Small and large rifampicin-loaded microspheres were obtained for each of the copolymers. The initial amount of drug was 10, 30 or 50 wt%, based on the weight of the polymer. Particles obtained in this study were round in shape with diameter in the range of 2–21 μm and of orange to red colour originating from rifampicin. The RIF encapsulation efficacy varied from 7% to 33%. Drug loading varied from 2% to 13% and increased at a higher RIF ratio. The highest degree of drug loading was observed for large particles, in which the initial amount of drug (at the particle preparation stage) was 50 wt%. Microspheres prepared from betulin-based polyanhydrides may have significant applications in drug delivery systems. The concentration of loaded drug was enough to obtain bactericidal effects against reference S. Aureus ATCC 25923 bacteria.
Keywords: betulin; polyanhydrides; biodegradable polymers; rifampicin; drug delivery systems betulin; polyanhydrides; biodegradable polymers; rifampicin; drug delivery systems

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MDPI and ACS Style

Niewolik, D.; Bednarczyk-Cwynar, B.; Ruszkowski, P.; Kazek-Kęsik, A.; Dzido, G.; Jaszcz, K. Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery. Pharmaceutics 2022, 14, 579. https://doi.org/10.3390/pharmaceutics14030579

AMA Style

Niewolik D, Bednarczyk-Cwynar B, Ruszkowski P, Kazek-Kęsik A, Dzido G, Jaszcz K. Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery. Pharmaceutics. 2022; 14(3):579. https://doi.org/10.3390/pharmaceutics14030579

Chicago/Turabian Style

Niewolik, Daria, Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Alicja Kazek-Kęsik, Grzegorz Dzido, and Katarzyna Jaszcz. 2022. "Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery" Pharmaceutics 14, no. 3: 579. https://doi.org/10.3390/pharmaceutics14030579

APA Style

Niewolik, D., Bednarczyk-Cwynar, B., Ruszkowski, P., Kazek-Kęsik, A., Dzido, G., & Jaszcz, K. (2022). Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-co-sebacic Acid) for Rifampicin Delivery. Pharmaceutics, 14(3), 579. https://doi.org/10.3390/pharmaceutics14030579

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