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Article

Cannabis-Based Oral Emulsion for Medical Purposes to Meet the Needs of Patients: Formulation, Quality and Stability

Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Academic Editor: Monica M. Jablonski
Pharmaceutics 2022, 14(3), 513; https://doi.org/10.3390/pharmaceutics14030513
Received: 22 December 2021 / Revised: 11 February 2022 / Accepted: 24 February 2022 / Published: 25 February 2022
Current Italian legislation provides that medical Cannabis can be administered orally as an extract if it has been titrated to determine the concentration of active molecules. In this context, there is a need to provide known and adequate quantities of active ingredients in order to guarantee uniform therapies that lead to the optimization of risks/benefits. This is fundamental considering that the limited availability on the market of registered Cannabis-based products for medical use means that prescribed therapies are usually prepared as galenic preparations. Consequently, the preparation procedures must be consistent with the instrumentation usually present in the laboratories of community pharmacies. In this context, the purpose of this work was to standardize the preparation procedure for oil-in-water (O/W) emulsions to exploit advantages in terms of ease of administration and dosage adjustment, but also to ensure the palatable organoleptic characteristics of the finished product. For the formulations being studied, in addition to the quality according to the directives set out in the European Pharmacopoeia, the stability was evaluated to assure adequate validity for therapeutic uses. View Full-Text
Keywords: medical Cannabis; Cannabis oil; THC; CBD; standard procedures; stability medical Cannabis; Cannabis oil; THC; CBD; standard procedures; stability
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MDPI and ACS Style

Baratta, F.; Peira, E.; Maza, C.; Gallarate, M.; Brusa, P. Cannabis-Based Oral Emulsion for Medical Purposes to Meet the Needs of Patients: Formulation, Quality and Stability. Pharmaceutics 2022, 14, 513. https://doi.org/10.3390/pharmaceutics14030513

AMA Style

Baratta F, Peira E, Maza C, Gallarate M, Brusa P. Cannabis-Based Oral Emulsion for Medical Purposes to Meet the Needs of Patients: Formulation, Quality and Stability. Pharmaceutics. 2022; 14(3):513. https://doi.org/10.3390/pharmaceutics14030513

Chicago/Turabian Style

Baratta, Francesca, Elena Peira, Carola Maza, Marina Gallarate, and Paola Brusa. 2022. "Cannabis-Based Oral Emulsion for Medical Purposes to Meet the Needs of Patients: Formulation, Quality and Stability" Pharmaceutics 14, no. 3: 513. https://doi.org/10.3390/pharmaceutics14030513

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