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Article

Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, Faculty of Health Sciences, School of Therapeutic Science, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa
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Academic Editors: Paola Brusa, Francesca Baratta, Fabio Firenzuoli and Valentina Maggini
Pharmaceutics 2022, 14(4), 703; https://doi.org/10.3390/pharmaceutics14040703
Received: 28 February 2022 / Revised: 21 March 2022 / Accepted: 22 March 2022 / Published: 25 March 2022
Current cannabidiol (CBD) formulations are challenged with unpredictable release and absorption. Rational design of a rectal colloid delivery system can provide a practical alternative. In this study the inherent physiochemical properties of transferosomes were harnessed for the development of a nano-sized transfersomes to yield more stable release, absorption, and bioavailability of CBD as a rectal colloid. Transfersomes composed of soya lecithin, cholesterol, and polysorbate 80 were synthesized via thin film evaporation and characterized for size, entrapment efficiency (%), morphology, CBD release, ex vivo permeation, and physicochemical stability. The optimized formulation for rectal delivery entrapped up to 80.0 ± 0.077% of CBD with a hydrodynamic particle size of 130 nm, a PDI value of 0.285, and zeta potential of −15.97 mV. The morphological investigation via SEM and TEM revealed that the transfersomes were spherical and unilamellar vesicles coinciding with the enhanced ex vivo permeation across the excised rat colorectal membrane. Furthermore, transfersomes improved the stability of the encapsulated CBD for up to 6 months at room temperature and showed significant promise that the transfersomes promoted rectal tissue permeation with superior stability and afforded tunable release kinetics of CBD as a botanical therapeutic with inherent poor bioavailability. View Full-Text
Keywords: cannabidiol; transfersomes; rectal colloid; nanoencapsulation; permeation; stability cannabidiol; transfersomes; rectal colloid; nanoencapsulation; permeation; stability
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MDPI and ACS Style

Moqejwa, T.; Marimuthu, T.; Kondiah, P.P.D.; Choonara, Y.E. Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol. Pharmaceutics 2022, 14, 703. https://doi.org/10.3390/pharmaceutics14040703

AMA Style

Moqejwa T, Marimuthu T, Kondiah PPD, Choonara YE. Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol. Pharmaceutics. 2022; 14(4):703. https://doi.org/10.3390/pharmaceutics14040703

Chicago/Turabian Style

Moqejwa, Thope, Thashree Marimuthu, Pierre P. D. Kondiah, and Yahya E. Choonara. 2022. "Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol" Pharmaceutics 14, no. 4: 703. https://doi.org/10.3390/pharmaceutics14040703

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