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Article

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance

1
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
2
Departamento de Microbiología, Facultad de Biología, Edificio CIBUS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
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Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
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CIIEM, Instituto Superior de Ciências da Saúde Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Charles Heard
Pharmaceutics 2021, 13(4), 532; https://doi.org/10.3390/pharmaceutics13040532
Received: 15 February 2021 / Revised: 3 April 2021 / Accepted: 6 April 2021 / Published: 11 April 2021
(This article belongs to the Special Issue Recent Advances in Ophthalmic Drug Delivery)
Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear® 1 day CLs). Both poly(hydroxyethyl methacrylate) (HEMA) and silicone hydrogels were prepared with MPC covering a wide range of concentrations (from 0 to 101 mM). All hydrogels showed physical properties adequate for CLs and successfully passed the hen’s egg-chorioallantoic membrane (HET-CAM) test. Silicone hydrogels had stronger affinity for resveratrol, with higher loading and a slower release rate. Ex vivo cornea and sclera permeability tests revealed that resveratrol released from the hydrogels readily accumulated in both tissues but did not cross through. The antibiofilm tests against Pseudomonas aeruginosa and Staphylococcus aureus evidenced that, in general, resveratrol decreased biofilm formation, which correlated with its concentration-dependent antibacterial capability. Preferential adsorption of lysozyme, compared to albumin, might also contribute to the antimicrobial activity. In addition, importantly, the loading of resveratrol in the hydrogels preserved the antioxidant activity, even against photodegradation. Overall, the designed hydrogels can host therapeutically relevant amounts of resveratrol to be sustainedly released on the eye, providing antibiofilm and antioxidant performance. View Full-Text
Keywords: antibiofilm; antioxidant; drug-eluting contact lenses; microbial keratitis; endophthalmitis; device-related ocular infections antibiofilm; antioxidant; drug-eluting contact lenses; microbial keratitis; endophthalmitis; device-related ocular infections
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MDPI and ACS Style

Vivero-Lopez, M.; Muras, A.; Silva, D.; Serro, A.P.; Otero, A.; Concheiro, A.; Alvarez-Lorenzo, C. Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance. Pharmaceutics 2021, 13, 532. https://doi.org/10.3390/pharmaceutics13040532

AMA Style

Vivero-Lopez M, Muras A, Silva D, Serro AP, Otero A, Concheiro A, Alvarez-Lorenzo C. Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance. Pharmaceutics. 2021; 13(4):532. https://doi.org/10.3390/pharmaceutics13040532

Chicago/Turabian Style

Vivero-Lopez, María, Andrea Muras, Diana Silva, Ana P. Serro, Ana Otero, Angel Concheiro, and Carmen Alvarez-Lorenzo. 2021. "Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance" Pharmaceutics 13, no. 4: 532. https://doi.org/10.3390/pharmaceutics13040532

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