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Asymmetry in Drug Permeability through the Cornea

Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
Department of Chemical Engineering, Colorado School of Mines, Golden, CO 80401, USA
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Author to whom correspondence should be addressed.
Academic Editor: Uday B. Kompella
Pharmaceutics 2021, 13(5), 694;
Received: 27 February 2021 / Revised: 6 May 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Recent Advances in Ophthalmic Drug Delivery)
The permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitutes a more meaningful parameter when dealing with intraocular drug-delivery systems (i.e., drug-loaded intraocular lenses, intraocular implants or injections). Herein, the permeability coefficients of two commonly administered anti-inflammatory drugs (i.e., bromfenac sodium and dexamethasone sodium) were determined ex vivo using Franz diffusion cells and porcine corneas in both inward and outward configurations. A significantly higher drug accumulation in the cornea was detected in the outward direction, which is consistent with the different characteristics of the corneal layers. Coherently, a higher permeability coefficient was obtained for bromfenac sodium in the outward direction, but no differences were detected for dexamethasone sodium in the two directions. Drug accumulation in the cornea can prolong the therapeutic effect of intraocular drug-release systems. View Full-Text
Keywords: cornea; drug permeability; drug accumulation; bromfenac sodium; dexamethasone sodium cornea; drug permeability; drug accumulation; bromfenac sodium; dexamethasone sodium
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MDPI and ACS Style

Toffoletto, N.; Chauhan, A.; Alvarez-Lorenzo, C.; Saramago, B.; Serro, A.P. Asymmetry in Drug Permeability through the Cornea. Pharmaceutics 2021, 13, 694.

AMA Style

Toffoletto N, Chauhan A, Alvarez-Lorenzo C, Saramago B, Serro AP. Asymmetry in Drug Permeability through the Cornea. Pharmaceutics. 2021; 13(5):694.

Chicago/Turabian Style

Toffoletto, Nadia, Anuj Chauhan, Carmen Alvarez-Lorenzo, Benilde Saramago, and Ana P. Serro. 2021. "Asymmetry in Drug Permeability through the Cornea" Pharmaceutics 13, no. 5: 694.

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