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Article

Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

1
School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK
2
Pharmaceutical Sciences, R&D BioPharmaceuticals, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Carmen Ferrero
Pharmaceutics 2021, 13(11), 1837; https://doi.org/10.3390/pharmaceutics13111837
Received: 2 September 2021 / Revised: 30 October 2021 / Accepted: 1 November 2021 / Published: 2 November 2021
(This article belongs to the Collection 3D Printing and Bioprinting Applications in Pharmaceutics)
3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays. View Full-Text
Keywords: hollow microneedles; transdermal drug delivery; 3D printing; additive manufacturing; digital light processing; emerging technologies hollow microneedles; transdermal drug delivery; 3D printing; additive manufacturing; digital light processing; emerging technologies
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MDPI and ACS Style

Mathew, E.; Pitzanti, G.; Gomes dos Santos, A.L.; Lamprou, D.A. Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays. Pharmaceutics 2021, 13, 1837. https://doi.org/10.3390/pharmaceutics13111837

AMA Style

Mathew E, Pitzanti G, Gomes dos Santos AL, Lamprou DA. Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays. Pharmaceutics. 2021; 13(11):1837. https://doi.org/10.3390/pharmaceutics13111837

Chicago/Turabian Style

Mathew, Essyrose, Giulia Pitzanti, Ana L. Gomes dos Santos, and Dimitrios A. Lamprou. 2021. "Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays" Pharmaceutics 13, no. 11: 1837. https://doi.org/10.3390/pharmaceutics13111837

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